Efficacy of novel albendazole salt formulations against secondary cystic echinococcosis in experimentally infected mice

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dc.authorid0000-0001-9183-7591
dc.authorid0000-0001-9183-7591
dc.authorid0000-0002-8698-9440
dc.authorid0000-0003-2672-5766
dc.authorid0000-0002-0622-2128
dc.authorid0000-0002-5947-4118
dc.authorscopusid23971786000
dc.authorscopusid57218705593
dc.authorscopusid57190291855
dc.authorscopusid57218705880
dc.authorscopusid12545052400
dc.authorscopusid57212700878
dc.authorscopusid12781515600
dc.authorwosidHAREM, Ismail Sah/ABG-8821-2020
dc.authorwosidCasulli, Adriano/AAQ-6859-2020
dc.authorwosidCarradori, Simone/S-4776-2019
dc.authorwosidCASULLI, ADRIANO/O-2278-2015
dc.authorwosidLundstrom-Stadelmann, Britta/E-8042-2011
dc.contributor.authorVural, G.
dc.contributor.authorYardımcı, Mehmet
dc.contributor.authorKoçak, Melek
dc.contributor.authorYaşar, Tuba Özge
dc.contributor.authorKurt, A.
dc.contributor.authorHarem, İsmail Şah
dc.contributor.authorCasulli, Adriano
dc.date.accessioned2022-05-11T14:42:29Z
dc.date.available2022-05-11T14:42:29Z
dc.date.issued2020
dc.departmentFakülteler, Veteriner Fakültesi, Temel Bilimler Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalı
dc.description.abstractIn this study, we evaluated the efficacy, expressed as a mean weight decrease of the whole echinococcal cyst mass, of novel benzimidazole salt formulations in a murine Echinococcus granulosus infection model. BALB/c mice were intraperitoneally infected with protoscoleces of E. granulosus (genotype G1). At 9 months post-infection, treatment with albendazole (ABZ), ricobendazole (RBZ) salt formulations, and RBZ enantiomer salts (R)-(+)-RBZ-Na and (S)-(-)-RBZ-Na formulations were initiated. Drugs were orally applied by gavage at 10 mg kg(-1) body weight per day during 30 days. Experimental treatments with benzimidazole sodium salts resulted in a significant reduction of the weight of cysts compared to conventional ABZ treatment, except for the (S)-(-)-RBZ-Na enantiomer formulation. Scanning electron microscopy and histological inspection revealed that treatments impacted not only the structural integrity of the parasite tissue in the germinal layer, but also induced alterations in the laminated layer. Overall, these results demonstrate the improved efficacy of benzimidazole salt formulations compared to conventional ABZ treatment in experimental murine cystic echinococcosis.
dc.description.sponsorshipEuropean UnionEuropean Commission [602051]
dc.description.sponsorshipThe research leading to these results received funding from the European Union Seventh Framework Programme (FP7/2007-2013) under the project HERACLES (http://www.heracles-fp7.eu/), grant agreement no. 602051. The funder of the study had no role in study design, data collection, data analysis, data interpretation or writing of the report.
dc.identifier.doi10.1017/S0031182020001225
dc.identifier.endpage1432
dc.identifier.issn0031-1820
dc.identifier.issn1469-8161
dc.identifier.issue13en_US
dc.identifier.pmid32729453
dc.identifier.scopus2-s2.0-85090156361
dc.identifier.scopusqualityQ1
dc.identifier.startpage1425
dc.identifier.urihttps://doi.org/10.1017/S0031182020001225
dc.identifier.urihttps://hdl.handle.net/20.500.11776/9390
dc.identifier.volume147
dc.identifier.wosWOS:000590482000006
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorKoçak, Melek
dc.institutionauthorYardımcı, Mehmet
dc.institutionauthorYaşar, T. O.
dc.language.isoen
dc.publisherCambridge Univ Press
dc.relation.ispartofParasitology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAlbendazole
dc.subjectEchinococcus granulosus
dc.subjectefficacy
dc.subjectenantiomers
dc.subjectmouse model
dc.subjectnew formulations
dc.subjectricobendazole
dc.subjectsalts of benzimidazoles
dc.subjectsalts of ricobendazole
dc.subjectsecondary cystic echinococcosis
dc.subjectSulfoxide Enantiomers
dc.subjectIn-Vitro
dc.subjectGranulosus
dc.subjectFlubendazole
dc.subjectNitazoxanide
dc.subjectBurden
dc.titleEfficacy of novel albendazole salt formulations against secondary cystic echinococcosis in experimentally infected mice
dc.typeArticle

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