Efficacy of novel albendazole salt formulations against secondary cystic echinococcosis in experimentally infected mice
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Dosyalar
Tarih
2020
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Cambridge Univ Press
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
In this study, we evaluated the efficacy, expressed as a mean weight decrease of the whole echinococcal cyst mass, of novel benzimidazole salt formulations in a murine Echinococcus granulosus infection model. BALB/c mice were intraperitoneally infected with protoscoleces of E. granulosus (genotype G1). At 9 months post-infection, treatment with albendazole (ABZ), ricobendazole (RBZ) salt formulations, and RBZ enantiomer salts (R)-(+)-RBZ-Na and (S)-(-)-RBZ-Na formulations were initiated. Drugs were orally applied by gavage at 10 mg kg(-1) body weight per day during 30 days. Experimental treatments with benzimidazole sodium salts resulted in a significant reduction of the weight of cysts compared to conventional ABZ treatment, except for the (S)-(-)-RBZ-Na enantiomer formulation. Scanning electron microscopy and histological inspection revealed that treatments impacted not only the structural integrity of the parasite tissue in the germinal layer, but also induced alterations in the laminated layer. Overall, these results demonstrate the improved efficacy of benzimidazole salt formulations compared to conventional ABZ treatment in experimental murine cystic echinococcosis.
Açıklama
Anahtar Kelimeler
Albendazole, Echinococcus granulosus, efficacy, enantiomers, mouse model, new formulations, ricobendazole, salts of benzimidazoles, salts of ricobendazole, secondary cystic echinococcosis, Sulfoxide Enantiomers, In-Vitro, Granulosus, Flubendazole, Nitazoxanide, Burden
Kaynak
Parasitology
WoS Q Değeri
Q2
Scopus Q Değeri
Q1
Cilt
147
Sayı
13