Efficacy of novel albendazole salt formulations against secondary cystic echinococcosis in experimentally infected mice

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Küçük Resim

Tarih

2020

Dergi Başlığı

Dergi ISSN

Cilt Başlığı

Yayıncı

Cambridge Univ Press

Erişim Hakkı

info:eu-repo/semantics/closedAccess

Özet

In this study, we evaluated the efficacy, expressed as a mean weight decrease of the whole echinococcal cyst mass, of novel benzimidazole salt formulations in a murine Echinococcus granulosus infection model. BALB/c mice were intraperitoneally infected with protoscoleces of E. granulosus (genotype G1). At 9 months post-infection, treatment with albendazole (ABZ), ricobendazole (RBZ) salt formulations, and RBZ enantiomer salts (R)-(+)-RBZ-Na and (S)-(-)-RBZ-Na formulations were initiated. Drugs were orally applied by gavage at 10 mg kg(-1) body weight per day during 30 days. Experimental treatments with benzimidazole sodium salts resulted in a significant reduction of the weight of cysts compared to conventional ABZ treatment, except for the (S)-(-)-RBZ-Na enantiomer formulation. Scanning electron microscopy and histological inspection revealed that treatments impacted not only the structural integrity of the parasite tissue in the germinal layer, but also induced alterations in the laminated layer. Overall, these results demonstrate the improved efficacy of benzimidazole salt formulations compared to conventional ABZ treatment in experimental murine cystic echinococcosis.

Açıklama

Anahtar Kelimeler

Albendazole, Echinococcus granulosus, efficacy, enantiomers, mouse model, new formulations, ricobendazole, salts of benzimidazoles, salts of ricobendazole, secondary cystic echinococcosis, Sulfoxide Enantiomers, In-Vitro, Granulosus, Flubendazole, Nitazoxanide, Burden

Kaynak

Parasitology

WoS Q Değeri

Q2

Scopus Q Değeri

Q1

Cilt

147

Sayı

13

Künye