Immunohistochemical distribution of platelet-derived growth factor-C and platelet-derived growth factor receptor-alpha in small intestine of rats treated with capsaicin

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dc.authorscopusid37121662100
dc.authorscopusid27667663200
dc.authorwosidbakır, buket/ABA-8248-2020
dc.contributor.authorBakır, Buket
dc.contributor.authorSarı, Ebru Karadağ
dc.date.accessioned2022-05-11T14:42:27Z
dc.date.available2022-05-11T14:42:27Z
dc.date.issued2015
dc.departmentFakülteler, Veteriner Fakültesi, Temel Bilimler Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalı
dc.description.abstractThe purpose of this study was to examine the effect of capsaicin administration immunohistochemically on platelet-derived growth factor (PDGF)-C and platelet-derived growth factor receptor (PDGFR)-alpha release in the small intestine tissues of rats. Rats were divided into three groups: group 1 (subcutaneous drug administration), group 2 (oral drug administration), and group 3 (subcutaneous sham administration). Histometric measurements and counts were performed in order to determine whether there was a difference between groups in terms of height of villi, depth of crypts, and goblet cell count in small intestine. The small intestine was examined by Crossman's triple staining method and streptavidin-biotin peroxidase complex method. As a result of statistical analysis, it was found that body weight increased in group 3, while it decreased in groups 1 and 2. Capsaicin administration increased height of villi, depth of crypts, and count of goblet cells located on villi and crypts. Immunohistochemical examinations revealed that capsaicin administration increased PDGF-C and PDGFR-alpha release. It was concluded that capsaicin has a stimulatory effect on growth and is an enhancer for PDGF-C and PDGFR-alpha release.
dc.identifier.doi10.3906/vet-1405-24
dc.identifier.endpage167
dc.identifier.issn1300-0128
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-84929301634
dc.identifier.scopusqualityQ3
dc.identifier.startpage160
dc.identifier.urihttps://doi.org/10.3906/vet-1405-24
dc.identifier.urihttps://hdl.handle.net/20.500.11776/9379
dc.identifier.volume39
dc.identifier.wosWOS:000353338100007
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorBakır, Buket
dc.language.isoen
dc.publisherScientific Technical Research Council Turkey-Tubitak
dc.relation.ispartofTurkish Journal of Veterinary & Animal Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCapsaicin
dc.subjectPDGF-C
dc.subjectPDGFR-alpha
dc.subjectsmall intestine
dc.subjectPungent Principle
dc.subjectCapsicum Fruits
dc.subjectPdgfr-Alpha
dc.subjectMetabolism
dc.subjectMice
dc.subjectAa
dc.titleImmunohistochemical distribution of platelet-derived growth factor-C and platelet-derived growth factor receptor-alpha in small intestine of rats treated with capsaicin
dc.typeArticle

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