Evaluation of the Effect of Daptomycin, a Glycopeptide Agent, on Intact Intervertebral Disc Tissue

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dc.authorid0000-0003-2003-6337
dc.authorid0000-0002-8084-7855
dc.authorid0000-0001-5590-0637
dc.authorid0000-0002-1224-442X
dc.authorscopusid57201362754
dc.authorscopusid35197435300
dc.authorscopusid56674583800
dc.authorscopusid56769801000
dc.authorscopusid57202435374
dc.authorscopusid56674439000
dc.authorscopusid8416126500
dc.authorwosidYILMAZ, Ibrahim/H-6199-2019
dc.authorwosidOzbek, Hanefi/O-3472-2019
dc.authorwosidKARAARSLAN, Numan/I-6819-2019
dc.authorwosidsirin, duygu yasar/AAR-8685-2020
dc.contributor.authorKaplan, Necati
dc.contributor.authorYılmaz, İbrahim
dc.contributor.authorKaraarslan, Numan
dc.contributor.authorYasar Şirin, Duygu
dc.contributor.authorŞimşek, Abdullah Talha
dc.contributor.authorÇalışkan, Tezcan
dc.contributor.authorÖzbek, Hanefi
dc.date.accessioned2022-05-11T14:12:15Z
dc.date.available2022-05-11T14:12:15Z
dc.date.issued2019
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Beyin ve Sinir Cerrahisi Ana Bilim Dalı
dc.departmentFakülteler, Fen Edebiyat Fakültesi, Biyoloji Bölümü
dc.description.abstractAIM: To evaluate the effects of pre- and intra-operatively administered daptomycin (DAP) on the intact human primary intervertebral disc tissue cells. MATERIAL and METHODS: Primary cell cultures were established using tissues obtained through decompressive laminectomy, traumatic intervertebral disc herniation excision, and posterior transpedicular stabilization. Non-drug-administered samples were used as a control group. The samples treated with DAP formed the study group. Molecular assays for proliferation and gene expression were performed. The obtained data were evaluated statistically, and results with a value of p<0.05 were accepted as significant. RESULTS: While no reduction was observed in the proliferation, the gene expression of intact intervertebral disc tissue cells was time-dependently decreased compared to the control group, and these results were reported to be statistically significant. CONCLUSION: This study observed the effect that a pharmaceutical preparation, which was used on intervertebral disc tissue before and after the operation, had on normal, healthy, and intact tissue. It concludes that alterations in the expression of genes involved in the anabolic and/or catabolic process, even in adjacent healthy tissue, may slow down the healing process of the damaged tissue or cause undesired cell differentiation.
dc.identifier.doi10.5137/1019-5149.JTN.24447-18.3
dc.identifier.endpage529
dc.identifier.issn1019-5149
dc.identifier.issue4en_US
dc.identifier.pmid30829382
dc.identifier.scopus2-s2.0-85068889170
dc.identifier.scopusqualityQ3
dc.identifier.startpage522
dc.identifier.urihttps://doi.org/10.5137/1019-5149.JTN.24447-18.3
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5465
dc.identifier.volume29
dc.identifier.wosWOS:000473763100010
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorKaraarslan, Numan
dc.institutionauthorYasar Şirin, Duygu
dc.institutionauthorŞimşek, Abdullah Talha
dc.institutionauthorÇalışkan, Tezcan
dc.language.isoen
dc.publisherTurkish Neurosurgical Soc
dc.relation.ispartofTurkish Neurosurgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectIntervertebral disc
dc.subjectCHAD
dc.subjectCOMP
dc.subjectDaptomycin
dc.subjectIL-1 beta
dc.subjectMMPs
dc.subjectHigh-Dose Daptomycin
dc.subjectArticular-Cartilage
dc.subjectInfections
dc.subjectTherapy
dc.subjectChondroadherin
dc.subjectOsteomyelitis
dc.subjectCeftriaxone
dc.subjectBacteremia
dc.subjectVancomycin
dc.subjectEfficacy
dc.titleEvaluation of the Effect of Daptomycin, a Glycopeptide Agent, on Intact Intervertebral Disc Tissue
dc.typeArticle

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