Synthesis of 7-azaindole based carbohydrazides and 1,3,4-oxadiazoles; Antioxidant activity, ?-glucosidase inhibition properties and docking study
Yükleniyor...
Dosyalar
Tarih
2022
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier B.V.
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
In this current work, 7-azaindole based 1,3,4-oxadiazoles have been successfully prepared by treatment of 3-(hydrazonomethyl)-7-azaindole with the different acyl chlorides or acetic anhydrides to give the corresponding carbohydrazides, followed by iodine mediated synthetic protocol in order to afford the corresponding 2,5-disubstituted 1,3,4-oxadiazoles. The full characterization data of the novel compounds were obtained by utilizing 1H NMR, 13C NMR, FT-IR, high-resolution mass spectrometry and single crystal X-ray diffraction techniques. The antioxidant activity and ?-glucosidase inhibition potential of the prepared compounds are examined by in vitro assays. The targeted hydrazide linked 7-azaindoles and their corresponding cyclized form 1,3,4-oxadiazoles exhibited inhibitory potential with IC50 values ranges between 0.46 and 24.92 mM. Plausible binding mode and interaction of ligands with ?-glucosidase enzyme have been studied by molecular docking, supporting the experimental results. © 2021 Elsevier B.V.
Açıklama
Anahtar Kelimeler
1,3,4-oxadiazole, 7-azaindole, Antioxidant activity, Docking study, ?-glucosidase inhibition, Binding energy, Chlorine compounds, Mass spectrometry, Single crystals, 'current, 1,3,4-oxadiazole, 7-azaindole, Antioxidant activities, Carbohydrazide, Docking studies, Glucosidase, Inhibition property, Oxadiazoles, ?-glucosidase inhibition, Antioxidants
Kaynak
Journal of Molecular Structure
WoS Q Değeri
Q3
Scopus Q Değeri
Q2
Cilt
1247