Synthesis of 7-azaindole based carbohydrazides and 1,3,4-oxadiazoles; Antioxidant activity, ?-glucosidase inhibition properties and docking study

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dc.authorscopusid57240814700
dc.authorscopusid55308985300
dc.authorscopusid37098938400
dc.authorscopusid56543023800
dc.authorscopusid56572574200
dc.authorscopusid55326408200
dc.contributor.authorİzgi, S.
dc.contributor.authorŞengül, İbrahim Fazıl
dc.contributor.authorŞahin, E.
dc.contributor.authorKoca, M.S.
dc.contributor.authorCebeci, F.
dc.contributor.authorKandemir, Hakan
dc.date.accessioned2022-05-11T14:04:41Z
dc.date.available2022-05-11T14:04:41Z
dc.date.issued2022
dc.departmentFakülteler, Fen Edebiyat Fakültesi, Kimya Bölümü
dc.description.abstractIn this current work, 7-azaindole based 1,3,4-oxadiazoles have been successfully prepared by treatment of 3-(hydrazonomethyl)-7-azaindole with the different acyl chlorides or acetic anhydrides to give the corresponding carbohydrazides, followed by iodine mediated synthetic protocol in order to afford the corresponding 2,5-disubstituted 1,3,4-oxadiazoles. The full characterization data of the novel compounds were obtained by utilizing 1H NMR, 13C NMR, FT-IR, high-resolution mass spectrometry and single crystal X-ray diffraction techniques. The antioxidant activity and ?-glucosidase inhibition potential of the prepared compounds are examined by in vitro assays. The targeted hydrazide linked 7-azaindoles and their corresponding cyclized form 1,3,4-oxadiazoles exhibited inhibitory potential with IC50 values ranges between 0.46 and 24.92 mM. Plausible binding mode and interaction of ligands with ?-glucosidase enzyme have been studied by molecular docking, supporting the experimental results. © 2021 Elsevier B.V.
dc.description.sponsorship19.220, NKUBAP.01; Türkiye Bilimsel ve Teknolojik Araştirma Kurumu, TÜBITAK: 120Z116
dc.description.sponsorshipThis work has been supported by The Scientific and Technological Research Council of Turkey (Project Number: 120Z116 ) and Tekirdag Namık Kemal University (Project Number: NKUBAP.01.GA.19.220 ).
dc.description.sponsorshipThis work has been supported by The Scientific and Technological Research Council of Turkey (Project Number: 120Z116) and Tekirdag Nam?k Kemal University (Project Number: NKUBAP.01.GA.19.220).
dc.identifier.doi10.1016/j.molstruc.2021.131343
dc.identifier.issn0022-2860
dc.identifier.scopus2-s2.0-85114035627
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1016/j.molstruc.2021.131343
dc.identifier.urihttps://hdl.handle.net/20.500.11776/4710
dc.identifier.volume1247
dc.identifier.wosWOS:000709586500009
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorİzgi, S.
dc.institutionauthorKandemir, Hakan
dc.language.isoen
dc.publisherElsevier B.V.
dc.relation.ispartofJournal of Molecular Structure
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subject1,3,4-oxadiazole
dc.subject7-azaindole
dc.subjectAntioxidant activity
dc.subjectDocking study
dc.subject?-glucosidase inhibition
dc.subjectBinding energy
dc.subjectChlorine compounds
dc.subjectMass spectrometry
dc.subjectSingle crystals
dc.subject'current
dc.subject1,3,4-oxadiazole
dc.subject7-azaindole
dc.subjectAntioxidant activities
dc.subjectCarbohydrazide
dc.subjectDocking studies
dc.subjectGlucosidase
dc.subjectInhibition property
dc.subjectOxadiazoles
dc.subject?-glucosidase inhibition
dc.subjectAntioxidants
dc.titleSynthesis of 7-azaindole based carbohydrazides and 1,3,4-oxadiazoles; Antioxidant activity, ?-glucosidase inhibition properties and docking study
dc.typeArticle

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