Electrochemical determination of aripiprazole based on aluminium oxide nanoparticles modified carbon paste electrode

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Tarih

2023

Dergi Başlığı

Dergi ISSN

Cilt Başlığı

Yayıncı

TUBITAK

Erişim Hakkı

info:eu-repo/semantics/openAccess

Özet

The electrochemical oxidation of aripiprazole was explored at a carbon paste electrode modified with aluminium oxide nanoparticles by cyclic voltammetry and square-wave anodic adsorptive stripping voltammetry. Experimental parameters such as carbon paste composition, scan rate, buffer pH, accumulation time, and accumulation potential were optimized in order to obtain high analytical performance. The incorporation of aluminium oxide nanoparticles into the carbon paste matrix enhanced the effective surface area of the carbon paste electrode and improved the sensitivity. On the aluminium oxide nanoparticles modified carbon paste electrode, aripiprazole exhibited an irreversible anodic peak at +1.17 V in pH 1.8 BR buffer solution. Under optimum conditions, the peak current exhibited a linear dependence with aripiprazole concentration between 0.03 and 8.0 µM with a detection limit of 0.006 ?M. The analytical applicability of the voltammetric method was evaluated by quantification of ARP in human serum samples and pharmaceutical formulations. © TÜBİTAK

Açıklama

Anahtar Kelimeler

aluminium oxide nanoparticles, Aripiprazole, biological fluid, carbon paste electrode, pharmaceutical formulation, square wave voltammetry

Kaynak

Turkish Journal of Chemistry

WoS Q Değeri

Q3

Scopus Q Değeri

Q3

Cilt

47

Sayı

1

Künye