Electrochemical determination of aripiprazole based on aluminium oxide nanoparticles modified carbon paste electrode
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Date
2023
Journal Title
Journal ISSN
Volume Title
Publisher
TUBITAK
Access Rights
info:eu-repo/semantics/openAccess
Abstract
The electrochemical oxidation of aripiprazole was explored at a carbon paste electrode modified with aluminium oxide nanoparticles by cyclic voltammetry and square-wave anodic adsorptive stripping voltammetry. Experimental parameters such as carbon paste composition, scan rate, buffer pH, accumulation time, and accumulation potential were optimized in order to obtain high analytical performance. The incorporation of aluminium oxide nanoparticles into the carbon paste matrix enhanced the effective surface area of the carbon paste electrode and improved the sensitivity. On the aluminium oxide nanoparticles modified carbon paste electrode, aripiprazole exhibited an irreversible anodic peak at +1.17 V in pH 1.8 BR buffer solution. Under optimum conditions, the peak current exhibited a linear dependence with aripiprazole concentration between 0.03 and 8.0 µM with a detection limit of 0.006 ?M. The analytical applicability of the voltammetric method was evaluated by quantification of ARP in human serum samples and pharmaceutical formulations. © TÜBİTAK
Description
Keywords
aluminium oxide nanoparticles, Aripiprazole, biological fluid, carbon paste electrode, pharmaceutical formulation, square wave voltammetry
Journal or Series
Turkish Journal of Chemistry
WoS Q Value
Q3
Scopus Q Value
Q3
Volume
47
Issue
1
