Effect of hesperetin on inflammatory and oxidative status in trinitrobenzene sulfonic acid-induced experimental colitis model

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dc.authorscopusid8855691800
dc.authorscopusid55838809000
dc.authorscopusid57204732288
dc.authorscopusid56816914100
dc.authorscopusid55858591400
dc.authorscopusid23968920100
dc.contributor.authorPolat, Fatin Rüştü
dc.contributor.authorKaraboğa, İhsan
dc.contributor.authorPolat, Muhammed Semih
dc.contributor.authorErboğa, Zeynep Fidanol
dc.contributor.authorYılmaz, Ahsen
dc.contributor.authorGüzel, Savaş
dc.date.accessioned2022-05-11T14:01:33Z
dc.date.available2022-05-11T14:01:33Z
dc.date.issued2018
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Genel Cerrahi Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.departmentYüksekokullar, Sağlık Yüksekokulu, Acil Yardım ve Afet Yönetimi Bölümü
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalı
dc.description.abstractIn our study, the effect of hesperetin on inflammatory and oxidative status in trinitrobenzene sulfonic acid (TNBS)-induced experimental colitis model was investigated through different methods. Eighteen Wistar albino male rats were divided in to three groups: Group I (Control, n = 8; 1 ml physiological saline), Group II (Colitis, n = 8; 1 ml TNBS), Group III (Hesperetin, n = 8; 1 ml TNBS and 100 mg/kg hesperetin). Macroscopic and microscopic scores were calculated to determine the damage to the colon at the end of the experiment. Serum tumor necrosis factor-? (TNF-?) and tissue interleukin-6 (IL-6) levels were determined using the ELISA method. Myeloperoxidase (MPO), superoxide dismutase (SOD), catalase (CAT) and malondialdehyde (MDA) levels were investigated spectrophotometrically. The TUNEL method was used for the detection of apoptotic cells in the colon tissue. Inducible nitric oxide synthase (iNOS) and nuclear factor-kappa-B (NF-??) expression in the colon were determined immunohistochemically. Hesperetin administration has shown to significantly reduce levels of MPO, MDA, and proinflammatory agents (TNF-?, IL-6, and NF-??). It has also been proven to inhibit mucosal apoptosis. This study indicates that hesperetin is protective against TNBS-induced colitis model via antiinflammatory, antioxidant and antiapoptotic effects. © 2018 by the C.M.B. Association. All rights reserved.
dc.description.sponsorshipWe acknowledge Scientific Research Project Department of Namık Kemal University for the grant given under project code NKUBAP.02.GA.17.085.
dc.identifier.doi10.14715/cmb/2018.64.11.11
dc.identifier.endpage65
dc.identifier.issn0145-5680
dc.identifier.issue11en_US
dc.identifier.pmid30213290
dc.identifier.scopus2-s2.0-85056820815
dc.identifier.scopusqualityQ4
dc.identifier.startpage58
dc.identifier.urihttps://doi.org/10.14715/cmb/2018.64.11.11
dc.identifier.urihttps://hdl.handle.net/20.500.11776/4437
dc.identifier.volume64
dc.identifier.wosWOS:000444259700011
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorPolat, Fatin Rüştü
dc.institutionauthorKaraboğa, İhsan
dc.institutionauthorPolat, Muhammed Semih
dc.institutionauthorErboğa, Zeynep Fidanol
dc.institutionauthorYılmaz, Ahsen
dc.institutionauthorGüzel, Savaş
dc.language.isoen
dc.publisherCellular and Molecular Biology Association
dc.relation.ispartofCellular and Molecular Biology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectHesperetin
dc.subjectIL-6
dc.subjectINOS
dc.subjectMPO
dc.subjectNF-??
dc.subjectTBNS-induced colitis
dc.subjectcatalase
dc.subjecthesperetin
dc.subjectimmunoglobulin enhancer binding protein
dc.subjectinducible nitric oxide synthase
dc.subjectinterleukin 6
dc.subjectmalonaldehyde
dc.subjectmyeloperoxidase
dc.subjectsuperoxide dismutase
dc.subjecttumor necrosis factor
dc.subjectantioxidant
dc.subjecthesperetin
dc.subjecthesperidin
dc.subjectimmunoglobulin enhancer binding protein
dc.subjectinducible nitric oxide synthase
dc.subjectinterleukin 6
dc.subjectmalonaldehyde
dc.subjectperoxidase
dc.subjectsuperoxide dismutase
dc.subjecttrinitrobenzenesulfonic acid
dc.subjecttumor necrosis factor
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectantiinflammatory activity
dc.subjectantioxidant activity
dc.subjectapoptosis
dc.subjectArticle
dc.subjectcolon mucosa
dc.subjectcolon ulcer
dc.subjectcontrolled study
dc.subjectenzyme linked immunosorbent assay
dc.subjectimmunohistochemistry
dc.subjectlipid peroxidation
dc.subjectnonhuman
dc.subjectoxidative stress
dc.subjectrat
dc.subjecttrinitrobenzene sulfonic acid-induced colitis
dc.subjectTUNEL assay
dc.subjectanimal
dc.subjectchemically induced
dc.subjectcolitis
dc.subjectdrug effect
dc.subjectmale
dc.subjectmetabolism
dc.subjectWistar rat
dc.subjectAnimals
dc.subjectAntioxidants
dc.subjectColitis
dc.subjectEnzyme-Linked Immunosorbent Assay
dc.subjectHesperidin
dc.subjectImmunohistochemistry
dc.subjectIn Situ Nick-End Labeling
dc.subjectInterleukin-6
dc.subjectLipid Peroxidation
dc.subjectMale
dc.subjectMalondialdehyde
dc.subjectNF-kappa B
dc.subjectNitric Oxide Synthase Type II
dc.subjectOxidative Stress
dc.subjectPeroxidase
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectSuperoxide Dismutase
dc.subjectTrinitrobenzenesulfonic Acid
dc.subjectTumor Necrosis Factor-alpha
dc.titleEffect of hesperetin on inflammatory and oxidative status in trinitrobenzene sulfonic acid-induced experimental colitis model
dc.typeArticle

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