Personalized medicine beyond genomics: alternative futures in big data-proteomics, environtome and the social proteome

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dc.authorid0000-0002-1712-5163
dc.authorid0000-0001-5456-8636
dc.authorid0000-0002-1225-5751
dc.authorid0000-0002-2645-4487
dc.authorscopusid57203613602
dc.authorscopusid49360947900
dc.authorscopusid6602243514
dc.authorscopusid7003286974
dc.authorscopusid56644104100
dc.authorscopusid36937817300
dc.authorscopusid7003626562
dc.authorwosidMete, Alper/AAH-7332-2020
dc.authorwosidSardas, Semra/J-2175-2018
dc.authorwosidYılmaz, Şenay Görücü/A-3797-2016
dc.authorwosidGungor, Kivanc/AAH-5406-2020
dc.authorwosidYılmaz, Şenay Görücü/R-5527-2016
dc.authorwosidBarlas, Ibrahim Omer/F-9237-2015
dc.contributor.authorÖzdemir, Vural
dc.contributor.authorDove, Edward S.
dc.contributor.authorGürsoy, Ulvi K.
dc.contributor.authorŞardaş, Semra
dc.contributor.authorYıldırım, Arif
dc.contributor.authorGörücü Yılmaz, Şenay
dc.contributor.authorSrivastava, Sanjeeva
dc.date.accessioned2022-05-11T14:32:39Z
dc.date.available2022-05-11T14:32:39Z
dc.date.issued2017
dc.departmentFakülteler, Güzel Sanatlar Tasarım ve Mimarlık Fakültesi, Radyo,Televizyon ve Sinema Bölümü
dc.description.abstractNo field in science and medicine today remains untouched by Big Data, and psychiatry is no exception. Proteomics is a Big Data technology and a next generation biomarker, supporting novel system diagnostics and therapeutics in psychiatry. Proteomics technology is, in fact, much older than genomics and dates to the 1970s, well before the launch of the international Human Genome Project. While the genome has long been framed as the master or elite executive molecule in cell biology, the proteome by contrast is humble. Yet the proteome is critical for life-it ensures the daily functioning of cells and whole organisms. In short, proteins are the blue-collar workers of biology, the down-to-earth molecules that we cannot live without. Since 2010, proteomics has found renewed meaning and international attention with the launch of the Human Proteome Project and the growing interest in Big Data technologies such as proteomics. This article presents an interdisciplinary technology foresight analysis and conceptualizes the terms environtome and social proteome. We define environtome as the entire complement of elements external to the human host, from microbiome, ambient temperature and weather conditions to government innovation policies, stock market dynamics, human values, political power and social norms that collectively shape the human host spatially and temporally. The social proteome is the subset of the environtome that influences the transition of proteomics technology to innovative applications in society. The social proteome encompasses, for example, new reimbursement schemes and business innovation models for proteomics diagnostics that depart from the once-a-life-time genotypic tests and the anticipated hype attendant to context and time sensitive proteomics tests. Building on the nesting principle for governance of complex systems as discussed by Elinor Ostrom, we propose here a 3-tiered organizational architecture for Big Data science such as proteomics. The proposed nested governance structure is comprised of (a) scientists, (b) ethicists, and (c) scholars in the nascent field of ethics-of-ethics, and aims to cultivate a robust social proteome for personalized medicine. Ostrom often noted that such nested governance designs offer assurance that political power embedded in innovation processes is distributed evenly and is not concentrated disproportionately in a single overbearing stakeholder or person. We agree with this assessment and conclude by underscoring the synergistic value of social and biological proteomes to realize the full potentials of proteomics science for personalized medicine in psychiatry in the present era of Big Data.
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK Program)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [2232]; Wellcome TrustWellcome TrustEuropean Commission [WT103360MA]
dc.description.sponsorshipSupported by an interdisciplinary career investigator award from the Scientific and Technological Research Council of Turkey (TUBITAK 2232 Program) to Vural Ozdemir. The analysis is independent views of the authors and do not necessarily reflect the position of their affiliated institutions or the funders. The concepts of environtome and social proteome were conceptualized and coined by V.O. The authors thank the anonymous peer-reviewers for constructive critique. Edward S. Dove acknowledges the Wellcome Trust Senior Investigator Award entitled Confronting the Liminal Spaces of Health Research Regulation'', Award No: WT103360MA, PI: Graeme Laurie.
dc.identifier.doi10.1007/s00702-015-1489-y
dc.identifier.endpage32
dc.identifier.issn0300-9564
dc.identifier.issn1435-1463
dc.identifier.issue1en_US
dc.identifier.pmid26645377
dc.identifier.scopus2-s2.0-84949505812
dc.identifier.scopusqualityQ2
dc.identifier.startpage25
dc.identifier.urihttps://doi.org/10.1007/s00702-015-1489-y
dc.identifier.urihttps://hdl.handle.net/20.500.11776/7642
dc.identifier.volume124
dc.identifier.wosWOS:000392516200004
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorYıldırım, Arif
dc.language.isoen
dc.publisherSpringer Wien
dc.relation.ispartofJournal of Neural Transmission
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectPrecision medicine
dc.subjectBig data
dc.subjectProteomics
dc.subjectTechnology foresight
dc.subjectFutures studies
dc.subjectInnovation management systems
dc.subjectQuantitative-Analysis
dc.subjectBiomarkers
dc.subjectDisorders
dc.subjectPostgenomics
dc.subjectInnovation
dc.subjectSignatures
dc.subjectBioethics
dc.subjectSociology
dc.subjectAgenda
dc.titlePersonalized medicine beyond genomics: alternative futures in big data-proteomics, environtome and the social proteome
dc.typeArticle

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