Role of quercetin in cadmium-induced oxidative stress, testicular damage, and apoptosis in rats

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dc.authorscopusid7006356462
dc.authorscopusid13609545500
dc.authorscopusid24436194200
dc.authorscopusid26646777500
dc.authorscopusid56814931200
dc.authorscopusid57006518400
dc.contributor.authorKanter, Mehmet
dc.contributor.authorAktoz, Tevfik
dc.contributor.authorAktaş, Cevat
dc.contributor.authorÖzen, F.
dc.contributor.authorYarali, O.
dc.contributor.authorKanter, Betül
dc.date.accessioned2022-05-11T14:42:04Z
dc.date.available2022-05-11T14:42:04Z
dc.date.issued2016
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalı
dc.description.abstractOBJECTIVE: The aim of this study was to investigate the role of quercetin on cadmium-induced oxidative stress, testicular damage, and apoptosis in rat testes. STUDY DESIGN: The rats were randomly allotted into 1 of 3 experimental groups: control, cadmium-treated, and cadmium-treated with quercetin; each group contained 10 animals. Control animals received daily injections of the saline vehicle alone. The cadmium-treated group was injected subcutaneously with cadmium chloride (CdCl2) dissolved in saline at a dose of 2 mL/kg/ day for 30 days, resulting in a dosage of 1 mg/kg cadmium. The rats in quercetin-treated groups were given quercetin (15 mg/kg body weight) once a day i.p., starting 2 days prior to the cadmium injection during the study period. All animals were sacrificed and testes tissues were removed for histopathological and biochemical (malondialdehyde [MDA], superoxide dismutase [SOD], glutathione peroxidase [GSH-Px], and serum testosterone levels) investigation. RESULTS: The mean seminiferous tubule diameter, Johnsen's mean testicular biopsy score values, biochemical parameters (MDA, SOD, GSH-Px, and serum testosterone levels), and amount of germ cell apoptosis were significantly decreased in the cadmium-treated groups as compared to the control group. Furthermore, the quercetin-treated animals showed improved histological and biochemical parameters in the cadmium-treated group. CONCLUSION: The present study showed that quercetin treatment protected testes against toxic effects of cadmium. We believe that further preclinical research into the utility of quercetin may indicate its usefulness as a potential treatment for spermatogenesis after testicular injury caused by cadmium-treated rats. © 2016 Science Printers and Publishers, Inc.
dc.identifier.endpage51
dc.identifier.issn0884-6812
dc.identifier.issue1en_US
dc.identifier.pmid27363066
dc.identifier.scopus2-s2.0-84961864620
dc.identifier.scopusqualityN/A
dc.identifier.startpage45
dc.identifier.urihttps://hdl.handle.net/20.500.11776/9197
dc.identifier.volume38
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAktaş, Cevat
dc.language.isoen
dc.publisherScience Printers and Publishers Inc.
dc.relation.ispartofAnalytical and Quantitative Cytology and Histology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subject3,3',4',5,7-Pentahydroxyflavone
dc.subjectAntioxidants
dc.subjectApoptosis
dc.subjectCadmium
dc.subjectCadmium poisoning
dc.subjectOxygenradicals
dc.subjectQuercetin
dc.subjectReactive oxygen species
dc.subjectTestes
dc.subjectTesticles
dc.subjectTestis
dc.subjectTestosterone
dc.subjectcadmium chloride
dc.subjectglutathione peroxidase
dc.subjectmalonaldehyde
dc.subjectquercetin
dc.subjectsuperoxide dismutase
dc.subjecttestosterone
dc.subjectquercetin
dc.subjectcadmium
dc.subjectglutathione peroxidase
dc.subjectmalonaldehyde
dc.subjectquercetin
dc.subjectsuperoxide dismutase
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectapoptosis
dc.subjectArticle
dc.subjectbiochemical analysis
dc.subjectcontrolled study
dc.subjectenzyme blood level
dc.subjectgerm cell
dc.subjecthistopathology
dc.subjectmale
dc.subjectnonhuman
dc.subjectoxidative stress
dc.subjectpriority journal
dc.subjectrat
dc.subjectseminiferous tubule
dc.subjecttestis biopsy
dc.subjecttestis injury
dc.subjecttestosterone blood level
dc.subjectanimal cell
dc.subjectantioxidant activity
dc.subjectenzyme activity
dc.subjectspermatogenesis
dc.subjecttestis injury
dc.subjecttestis size
dc.subjectanimal
dc.subjectapoptosis
dc.subjectdrug effects
dc.subjecthuman
dc.subjectmetabolism
dc.subjectoxidative stress
dc.subjectpathology
dc.subjecttestis
dc.subjectAnimals
dc.subjectApoptosis
dc.subjectCadmium
dc.subjectGlutathione Peroxidase
dc.subjectHumans
dc.subjectMale
dc.subjectMalondialdehyde
dc.subjectOxidative Stress
dc.subjectQuercetin
dc.subjectRats
dc.subjectSeminiferous Tubules
dc.subjectSuperoxide Dismutase
dc.subjectTestis
dc.titleRole of quercetin in cadmium-induced oxidative stress, testicular damage, and apoptosis in rats
dc.typeArticle

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