A comparison of the vasodilatory effects of verapamil, papaverine and nitroglycerin on isolated rat aorta

Basit Öğe Kaydı
dc.authorid0000-0002-1289-8829
dc.authorid0000-0002-1289-8829
dc.authorscopusid7004591561
dc.authorscopusid7003652889
dc.authorscopusid10139012600
dc.authorscopusid14008084500
dc.authorscopusid55317577700
dc.authorscopusid7005322966
dc.authorwosidgur, ozcan/AAA-8847-2022
dc.authorwosidHalici, Umit/AAL-7079-2020
dc.authorwosidGurkan, Selami/AAA-9006-2022
dc.authorwosidHalici, Umit/C-4015-2019
dc.contributor.authorEge, Turan
dc.contributor.authorHalıcı, Umit
dc.contributor.authorGür, Özcan
dc.contributor.authorGürkan, Selami
dc.contributor.authorÖzkaramanlı Gür, Demet
dc.contributor.authorDuran, Enver
dc.date.accessioned2022-05-11T14:35:56Z
dc.date.available2022-05-11T14:35:56Z
dc.date.issued2013
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kalp ve Damar Cerrahisi Ana Bilim Dalı
dc.description.abstractBackground: This study aims to compare the vasodilatory effects of verapamil, papaverine and nitroglycerin on rat aortic preparations in in vitro isolated tissue bath system and to evaluate the role of vascular endothelium on vasodilatory responses of the isolated rat aorta samples. Methods: The thoracic aorta segments collected from 30 male Wistar rats (20 endothelialized and 20 de-endothelialized vascular rings for each drug in 2 mm wide strips, total number of 120 vascular rings) were suspended into the Krebs solution of the isolated tissue bath system. Phenylephrine was used to induce isometric contraction and tissue samples were treated with verapamil, papaverine and nitroglycerin separately to draw concentration-response curves of isometric vasodilatory responses. This procedure was repeated for de-endothelialized aorta samples. Results: Papaverine and verapamil induced vasodilatatory responses starting from the concentration of 10(-8) M and reached its maximum at concentration of 10(-3) M, while nitroglycerin induced vasodilation at lower concentrations starting from a concentration of 10(-12) M, reaching its maximum at 10(-6) M. Nitroglycerin was the most potent agent, followed by verapamil and papaverine. Efficacy analysis revealed that the most efficient agents were papaverine (140 +/- 6.7%), nitroglycerin (110.8 +/- 1.35%) and verapamil (99 +/- 4.14%), respectively. The results were similar in aorta samples without endothelium (p >= 0.05, F test). Conclusion: In this study examining isolated rat aorta, nitroglycerin was the most potent agent, while papaverine was the most efficient agent. Our study results showed that endothelium played no role in vasodilatation responses of these drugs.
dc.identifier.doi10.5606/tgkdc.dergisi.2013.7870
dc.identifier.endpage1009
dc.identifier.issn1301-5680
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-84889608443
dc.identifier.scopusqualityQ3
dc.identifier.startpage1005
dc.identifier.urihttps://doi.org/10.5606/tgkdc.dergisi.2013.7870
dc.identifier.urihttps://hdl.handle.net/20.500.11776/8306
dc.identifier.volume21
dc.identifier.wosWOS:000326410100023
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorGür, Özcan
dc.institutionauthorGürkan, Selami
dc.language.isoen
dc.publisherBaycinar Medical Publ-Baycinar Tibbi Yayincilik
dc.relation.ispartofTurk Gogus Kalp Damar Cerrahisi Dergisi-Turkish Journal of Thoracic and Cardiovascular Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAorta
dc.subjectnitroglycerin
dc.subjectpapaverine
dc.subjectvasodilatation
dc.subjectverapamil
dc.subjectInternal Thoracic Artery
dc.subjectRabbit Aorta
dc.subjectRelaxation
dc.subjectEndothelium
dc.subjectPhenoxybenzamine
dc.subjectTolerance
dc.subjectResponses
dc.subjectNitrate
dc.titleA comparison of the vasodilatory effects of verapamil, papaverine and nitroglycerin on isolated rat aorta
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
8306.pdf
Boyut:
340.05 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
Tıp Fakültesi Koleksiyonu
TR-Dizin İndeksli Yayınlar Koleksiyonu