Novel carbazole containing zinc phthalocyanine photosensitizers: Synthesis, characterization, photophysicochemical properties and in vitro study

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dc.authorid0000-0001-9386-4892
dc.authorid0000-0002-7347-2223
dc.authorid0000-0003-2965-1993
dc.authorscopusid55330284900
dc.authorscopusid55308985300
dc.authorscopusid55326408200
dc.authorscopusid34569135700
dc.authorwosidDurmuş, Mahmut/AAG-3377-2019
dc.authorwosidSengul, Ibrahim Fazil/AAG-4368-2019
dc.authorwosidGöksel, Meltem/C-1548-2018
dc.authorwosidk, h/ABA-1339-2020
dc.contributor.authorGöksel, Meltem
dc.contributor.authorŞengül, İbrahim Fazıl
dc.contributor.authorKandemir, Hakan
dc.contributor.authorDurmuş, Mahmut
dc.date.accessioned2022-05-11T14:30:55Z
dc.date.available2022-05-11T14:30:55Z
dc.date.issued2016
dc.departmentFakülteler, Fen Edebiyat Fakültesi, Kimya Bölümü
dc.description.abstractTetra and octa substituted novel zinc(II) phthalocyanines (3a and 5a) bearing carbazole groups were synthesized by cyclotetramerization of respective phthalonitrile derivatives (3 and 5). The zinc(II) phthalocyanines (3a and 5a) were converted into the water-soluble quaternized derivatives (3b and 5b) by utilizing dimethylsulphate as quaternizing agent. The synthesized novel compounds were confirmed thruogh FT-IR, UV-vis and MALDI-TOF mass spectroscopic data and elemental analysis as well. The photophysical (fluorescence quantum yields and lifetimes) and photochemical (singlet oxygen generation) properties of new phthalocyanines were determined in dimethylsulfoxide (DMSO). The photophysical and photochemical results were compared according to the number of the carbazole groups on the phthalocyanine core. Additionaly, in vitro photocytotoxicity of the targeted compounds were examined against to hepato cellular carcinoma (HuH-7) cancer cell line for determination of their photosensitizing ability.
dc.identifier.doi10.1142/S1088424616500401
dc.identifier.endpage718
dc.identifier.issn1088-4246
dc.identifier.issn1099-1409
dc.identifier.issue6en_US
dc.identifier.scopus2-s2.0-84980338866
dc.identifier.scopusqualityQ3
dc.identifier.startpage708
dc.identifier.urihttps://doi.org/10.1142/S1088424616500401
dc.identifier.urihttps://hdl.handle.net/20.500.11776/7233
dc.identifier.volume20
dc.identifier.wosWOS:000381872800007
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorKandemir, Hakan
dc.language.isoen
dc.publisherWorld Sci Publ Co Inc
dc.relation.ispartofJournal of Porphyrins and Phthalocyanines
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectphthalocyanine
dc.subjectzinc
dc.subjectquaternization
dc.subjectphotosensitizer
dc.subjectphotocytotoxicity
dc.subjectHuH-7
dc.subjectMetal Phthalocyanines
dc.subjectPhotodynamic Therapy
dc.subjectSubstituents
dc.titleNovel carbazole containing zinc phthalocyanine photosensitizers: Synthesis, characterization, photophysicochemical properties and in vitro study
dc.typeArticle

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