Dose related inhibitor effect of enrofloxacin on in vitro feline spontaneous myometrial contractility

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dc.authorscopusid57194180999
dc.authorscopusid6506437429
dc.authorscopusid57209771954
dc.authorscopusid57447855300
dc.authorscopusid6602416499
dc.contributor.authorDoğan, Halef
dc.contributor.authorÖcal, H.
dc.contributor.authorŞafak, T.
dc.contributor.authorKılınç, M.A.
dc.contributor.authorRişvanlı, A.
dc.date.accessioned2022-05-11T14:42:15Z
dc.date.available2022-05-11T14:42:15Z
dc.date.issued2022
dc.departmentFakülteler, Veteriner Fakültesi, Klinik Bilimler Bölümü, Doğum ve Jinekoloji Ana Bilim Dalı
dc.description.abstractEnrofloxacin is one of the most widely used antibacterial drugs in feline medicine. This study investigated the effects of enrofloxacin on in vitro feline spontaneous myometrial contractility at different sexual stages. Uterine samples of the 20 queen cats at different sexual periods were placed in a tissue bath, and in vitro spontaneous stretch-induced myometrial contractions were recorded for 10 min. The tissue bath was adjusted for cumulative enrofloxacin concentrations of 0.25 mM, 0.50 mM, 1.00 mM, and 2.00 mM, respectively. Myometrial contractions were recorded for 10 min after each dose was adjusted in the tissue bath. It was observed that enrofloxacin caused a significant decrease in the peak amplitude and area under curve, while causing an increase the frequency of stretch-induced myometrial contractions in a dose dependent manner in vitro at all sexual stages. The current preliminary study concluded that enrofloxacin has an inhibitory effect on in vitro feline uterine myometrial activity at all sexual stages. It is recommended to take this medical effect into consideration and apply enrofloxacin and uterotonics together in treatment of uterine infections in feline medicine. © 2022 Elsevier B.V.
dc.description.sponsorshipWe would like to thank Cuneyt Disbudak for assistance of language revision. The authors declare that there is no conflict of interest.
dc.identifier.doi10.1016/j.anireprosci.2022.106972
dc.identifier.issn0378-4320
dc.identifier.scopus2-s2.0-85127308733
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.anireprosci.2022.106972
dc.identifier.urihttps://hdl.handle.net/20.500.11776/9299
dc.identifier.volume239
dc.indekslendigikaynakScopus
dc.institutionauthorDoğan, Halef
dc.language.isoen
dc.publisherElsevier B.V.
dc.relation.ispartofAnimal Reproduction Science
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectContractility
dc.subjectEnrofloxacin
dc.subjectIn vitro
dc.subjectQueen cat
dc.subjectUterus
dc.titleDose related inhibitor effect of enrofloxacin on in vitro feline spontaneous myometrial contractility
dc.typeArticle

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