New spectrofluorimetric method for the determination of nizatidine in bulk form and in pharmaceutical preparations

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dc.authorscopusid55235059200
dc.authorscopusid34574169900
dc.contributor.authorKarasakal, Ayça
dc.contributor.authorUlu, Sevgi Tatar
dc.date.accessioned2022-05-11T14:29:51Z
dc.date.available2022-05-11T14:29:51Z
dc.date.issued2013
dc.departmentFakülteler, Fen Edebiyat Fakültesi, Kimya Bölümü
dc.description.abstractA simple, accurate and highly sensitive spectrofluorimetric method has been developed for determination of nizatidine in pure form and in pharmaceutical dosage forms. The method is based on the reaction between nizatidine and 1-dimethylaminonaphthalene-5-sulphonyl chloride in carbonate buffer, pH 10.5, to yield a highly fluorescent derivative peaking at 513 nm after excitation at 367 nm. Various factors affecting the fluorescence intensity of nizatidin-dansyl derivative were studied and conditions were optimized. The method was validated as per ICH guidelines. The fluorescence concentration plot was rectilinear over the range of 25-300 ng/mL. Limit of detection and limit of quantification were calculated as 11.71 and 35.73 ng/mL, respectively. The proposed method was successfully applied to pharmaceutical preparations.
dc.identifier.doi10.1134/S0030400X13080031
dc.identifier.endpage309
dc.identifier.issn0030-400X
dc.identifier.issn1562-6911
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-84893133004
dc.identifier.scopusqualityQ4
dc.identifier.startpage306
dc.identifier.urihttps://doi.org/10.1134/S0030400X13080031
dc.identifier.urihttps://hdl.handle.net/20.500.11776/7153
dc.identifier.volume115
dc.identifier.wosWOS:000323425000023
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorKarasakal, Ayça
dc.language.isoen
dc.publisherPleiades Publishing Inc
dc.relation.ispartofOptics and Spectroscopy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectSpectrophotometric Determination
dc.subjectRanitidine-Hcl
dc.subjectFamotidine
dc.subjectCimetidine
dc.subjectMetabolites
dc.titleNew spectrofluorimetric method for the determination of nizatidine in bulk form and in pharmaceutical preparations
dc.typeArticle

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