Serum Irisin and Oxytocin Levels as Predictors of Metabolic Parameters in Obese Children

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dc.authorid0000-0003-3587-6830
dc.authorscopusid36625024500
dc.authorscopusid36161405300
dc.authorscopusid23968920100
dc.authorscopusid6603596874
dc.authorwosidPaketci, Cem/A-1490-2018
dc.contributor.authorBinay, Çiğdem
dc.contributor.authorPaketci, Cem
dc.contributor.authorGüzel, Savaş
dc.contributor.authorSamancı, Nedim
dc.date.accessioned2022-05-11T14:14:03Z
dc.date.available2022-05-11T14:14:03Z
dc.date.issued2017
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.description.abstractObjective: Irisin and oxytocin can affect energy homeostasis and it has been suggested that they may play an important role in reducing obesity and diabetes. In this study, we aimed to determine the relationship between metabolic parameters (including irisin and oxytocin levels) and anthropometric parameters in obese children. Methods: Ninety obese children (mean age, 13.85 +/- 1.63 years) and 30 healthy controls (mean age, 14.32 +/- 1.58 years) were enrolled in this study. Anthropometric and laboratory parameters (glucose, insulin, lipid, oxytocin, and irisin levels) were analyzed. The serum irisin and oxytocin levels were measured by enzyme-linked immunosorbent assay. Bioelectrical impedance was used to determine body composition. Results: Irisin level was higher in the patients than in the controls (p = 0.018), and this higher irisin level was correlated with increased systolic blood pressure, body mass index, waist/hip ratio, fat percentage, fat mass, glucose level, insulin level, and homeostasis model assessment of insulin resistance. Serum oxytocin level was significantly decreased in obese children compared to the controls (p = 0.049). Also, among the 60 obese patients, oxytocin level was significantly lower in patients with than in those without metabolic syndrome (8.65 +/- 2.69 vs. 10.87 +/- 5.93 ng/L, respectively), while irisin levels were comparable (p = 0.049 and p = 0.104, respectively). There were no statistically significant relationships between oxytocin or irisin levels and lipid levels (p > 0.05). Conclusion: Obese children had significantly higher irisin levels than the healthy controls. Additionally, this study shows for the first time that oxytocin level is significantly lower in obese compared with non-obese children and also lower in obese children with metabolic syndrome compared to those without.
dc.identifier.doi10.4274/jcrpe.3963
dc.identifier.endpage131
dc.identifier.issn1308-5727
dc.identifier.issn1308-5735
dc.identifier.issue2en_US
dc.identifier.pmid28077341
dc.identifier.scopus2-s2.0-85020194916
dc.identifier.scopusqualityQ2
dc.identifier.startpage124
dc.identifier.urihttps://doi.org/10.4274/jcrpe.3963
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5758
dc.identifier.volume9
dc.identifier.wosWOS:000406446700006
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorPaketci, Cem
dc.institutionauthorGüzel, Savaş
dc.institutionauthorSamancı, Nedim
dc.language.isoen
dc.publisherGalenos Yayincilik
dc.relation.ispartofJournal of Clinical Research in Pediatric Endocrinology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectChild obesity
dc.subjectirisin
dc.subjectoxytocin
dc.subjectfat mass
dc.subjectCirculating Irisin
dc.subjectInsulin-Resistance
dc.subjectWeight-Loss
dc.subjectExpression
dc.subjectExercise
dc.subjectFndc5
dc.subjectFat
dc.subjectAdiponectin
dc.subjectAdipokines
dc.subjectHumans
dc.titleSerum Irisin and Oxytocin Levels as Predictors of Metabolic Parameters in Obese Children
dc.typeArticle

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