New antimony(III) halide complexes with dithiocarbamate ligands derived from thiuram degradation: the effect of the molecule's close contacts on in vitro cytotoxic activity

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dc.authorid0000-0003-3264-2406
dc.authorid0000-0001-9556-6266
dc.authorid0000-0003-3164-0038
dc.authorid0000-0002-4804-3822
dc.authorid0000-0001-6727-2711
dc.authorid0000-0003-1188-6233
dc.authorscopusid55227384500
dc.authorscopusid36785856200
dc.authorscopusid46860923200
dc.authorscopusid6507202525
dc.authorscopusid14525091600
dc.authorscopusid6602706096
dc.authorscopusid6602925165
dc.authorwosidürgüt, ozan suleyman/ABA-5795-2020
dc.authorwosidKourkoumelis, Nikolaos/B-8555-2009
dc.authorwosidOzturk, Ibrahim Ismet/K-1352-2013
dc.authorwosidHadjikakou, Sotiris K./I-2909-2019
dc.contributor.authorUrgut, O. S.
dc.contributor.authorÖztürk, İbrahim İsmet
dc.contributor.authorBanti, Christina N.
dc.contributor.authorKourkoumelis, Nikolaos
dc.contributor.authorManoli, Maria
dc.contributor.authorTasiopoulos, Anastasios J.
dc.contributor.authorHadjikakou, Sotiris K.
dc.date.accessioned2022-05-11T14:30:55Z
dc.date.available2022-05-11T14:30:55Z
dc.date.issued2016
dc.departmentFakülteler, Fen Edebiyat Fakültesi, Kimya Bölümü
dc.description.abstractAntimony(III) halide complexes of the formulae {[SbBr(Me2DTC)(2)](n)} (1), {[SbI(Me2DTC)(2)](n)} (2) and {[(Me2DTC)(2)Sb(mu(2)-I)Sb(Me2DTC)(2)](+)center dot I-3(-)} (3) (Me2DTC = dimethyldithiocarbomate) were synthesized from SbX3, (X = Br or I) and tetramethylthiuram monosulfide (Me(4)tms) or tetramethylthiuram disulfide (Me(4)tds). The complexes were characterized by melting point (m.p.), elemental analysis (e.a.), Fourier-transform InfraRed (FT-IR), Fourier-transform Raman (FT-Raman), Nuclear Magnetic Resonance (H-1,C-13-NMR) spectroscopy and Thermogravimetric-Differential Thermal Analysis (TG-DTA). Crystal structures of complexes 1-3 were determined with single crystal X-ray diffraction analysis. Complexes 1 and 2 are polymers with distorted square pyramidal (SP) geometry in each monomeric unit, whereas complex 3 is ionic, containing an iodonium linkage SbI+-Sb and an I-3(-) counter anion; to the best of our knowledge, this is the first ionic antimony(III) iodide complex. The in vitro cytotoxic activity of 1-3 against human adenocarcinoma cells: breast (MCF-7) and cervix (HeLa) cells and non-cancerous cells: MRC-5 (normal human fetal lung fibroblast cells) was evaluated with trypan blue (TB) and sulforhodamine B (SRB) assays. Among antimony(III) compounds with sulfur containing ligand, those of dithiocarbamates exhibit significant cytotoxic activity. Hirshfeld surface volumes were analyzed to clarify the nature of the intermolecular interactions by the 2D fingerprint plot. Molecules with lower H-all atoms intermolecular interactions exhibit the higher activity against MCF-7 cells. The in vivo genotoxicity of 1-3 was evaluated by the mean of Allium cepa test. Alterations in the mitotic index values due to the chromosomal aberrations were observed in the case of complexes 2 and 3. Since, no such alteration is caused by 1, it makes this compound candidate for further study as potential drug. (C) 2015 Elsevier B.V. All rights reserved.
dc.description.sponsorshipNamik Kemal University Scientific Research ProjectNamik Kemal University [NKUBAP.00.10.YL.12.03]; National Scholarships Foundation of Greece (IKY)
dc.description.sponsorshipThis research was carried out in partial fulfillment of the requirements for the Master thesis of O.S.U., under the supervision of at the Namik Kemal University. I.I.O. and O.S.U. acknowledge the financial support from Namik Kemal University Scientific Research Project (Project No. NKUBAP.00.10.YL.12.03). CNB and SKH would like to thank the Unit of Bioactivity Testing of Xenobiotics, the University of Ioannina, for providing access to the facilities. CNB and SKH acknowledge the National Scholarships Foundation of Greece (IKY) for the post-doctoral research fellowship of excellence program IKY-Siemens.
dc.identifier.doi10.1016/j.msec.2015.08.030
dc.identifier.endpage408
dc.identifier.issn0928-4931
dc.identifier.issn1873-0191
dc.identifier.pmid26478326
dc.identifier.scopus2-s2.0-84941117450
dc.identifier.scopusqualityQ1
dc.identifier.startpage396
dc.identifier.urihttps://doi.org/10.1016/j.msec.2015.08.030
dc.identifier.urihttps://hdl.handle.net/20.500.11776/7231
dc.identifier.volume58
dc.identifier.wosWOS:000364247500047
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorÖztürk, İbrahim İsmet
dc.institutionauthorÜrgüt, Ozan
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofMaterials Science & Engineering C-Materials For Biological Applications
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectBiomaterials
dc.subjectAntimony(III) halide complexes
dc.subjectThiuram sulfides
dc.subjectCytotoxicity
dc.subjectGenotoxicity
dc.subjectStructural-Characterization
dc.subjectCrystal-Structure
dc.subjectBreast-Cancer
dc.subjectBismuth(Iii)
dc.subjectChloride
dc.subjectOrganotin(Iv)
dc.subjectChemistry
dc.subjectSulfides
dc.subjectThiourea
dc.titleNew antimony(III) halide complexes with dithiocarbamate ligands derived from thiuram degradation: the effect of the molecule's close contacts on in vitro cytotoxic activity
dc.typeArticle

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