Preventive effects of enoxaparin and hesperidin in cerulein-induced acute pancreatitis in rats

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dc.authorid0000-0002-4760-3306
dc.authorid0000-0002-5878-7489
dc.authorscopusid19234891200
dc.authorscopusid6505675113
dc.authorscopusid56235741300
dc.authorscopusid56037630800
dc.authorscopusid7006176088
dc.authorscopusid6505850610
dc.authorscopusid56039744700
dc.authorwosidYuksel, Meral/Z-3692-2019
dc.authorwosidŞen, Ebru/ABB-6373-2021
dc.contributor.authorKöksoy, Ferda Nihat
dc.contributor.authorYankol, Yücel
dc.contributor.authorSen Oran, Ebru
dc.contributor.authorGürdal, Sibel Özkan
dc.contributor.authorYüksel, Meral
dc.contributor.authorAkyildiz Igdem, Aysenur
dc.contributor.authorSoybir, Gürsel Remzi
dc.date.accessioned2022-05-11T14:34:53Z
dc.date.available2022-05-11T14:34:53Z
dc.date.issued2013
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Genel Cerrahi Ana Bilim Dalı
dc.description.abstractBackground/aims: Acute pancreatitis accounts for almost 250.000 hospital admissions annually in the United States. Most promising treatment approaches are preventive; however, little is known about the early factors initiating acute pancreatitis. We aimed to evaluate the preventive effects of enoxaparin and hesperidin in cerulein-induced acute pancreatitis. Patients and methods: We used 70 Wistar albino rats for this study. Rats were divided into 7 groups: control group, and groups that were administered cerulein (Group 2), enoxaparin (Group 3), hesperidin (Group 4), cerulein with enoxaparin (Group 5), cerulein with hesperidin (Group 6), and cerulein with both enoxaparin and hesperidin (Group 7). Edema formation; leukocyte infiltration; measurement of the amylase level, pancreatic tissue weight, and pancreatic tissue oxidative capacity; and chemiluminescence using luminol, lucigenin, and nitric oxide levels as indices of tissue oxidative capacity were used to evaluate pancreatitis. Results: Acute edematous mild pancreatitis was induced in groups 2, 5, and 6 by cerulein injections. Enoxaparin and hesperidin significantly decreased (p <0.001) all the tested parameters in these rats. Enoxaparin and hesperidin did not offer complete protection but showed 50% decrease in edema formation. The preventive agents showed no superiority to each other. Further, when enoxaparin and hesperidin were used in combination, no significant additive effects with regard to anti-inflammatory and anti-oxidative actions were present. Conclusion: We showed that both enoxaparin and hesperidin exerted significant preventive effects in all the parameters related to acute pancreatitis in our experimental rat model.
dc.identifier.doi10.4318/tjg.2013.0585
dc.identifier.endpage501
dc.identifier.issn1300-4948
dc.identifier.issn2148-5607
dc.identifier.issue6en_US
dc.identifier.pmid24623288
dc.identifier.scopus2-s2.0-84894153949
dc.identifier.scopusqualityQ3
dc.identifier.startpage495
dc.identifier.urihttps://doi.org/10.4318/tjg.2013.0585
dc.identifier.urihttps://hdl.handle.net/20.500.11776/8129
dc.identifier.volume24
dc.identifier.wosWOS:000331851200007
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorGürdal, Sibel Özkan
dc.institutionauthorSoybir, Gürsel Remzi
dc.language.isoen
dc.publisherAves
dc.relation.ispartofTurkish Journal of Gastroenterology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAcute pancreatitis
dc.subjectenoxaparin
dc.subjecthesperidin
dc.subjectPurified Flavonoid Fraction
dc.subjectNecrotizing Pancreatitis
dc.subjectFree-Radicals
dc.subjectCoagulation
dc.subjectHeparin
dc.subjectMicrocirculation
dc.subjectInflammation
dc.subjectProteins
dc.titlePreventive effects of enoxaparin and hesperidin in cerulein-induced acute pancreatitis in rats
dc.typeArticle

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