MicroRNA 21 and microRNA 155 levels in resistant hypertension, and their relationships with aldosterone

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dc.authorscopusid57190404723
dc.authorscopusid8570900600
dc.authorscopusid55858591400
dc.authorscopusid34869282100
dc.authorscopusid23968920100
dc.authorscopusid16039387600
dc.contributor.authorKara, Sonat Pınar
dc.contributor.authorÖzkan, Gülsüm
dc.contributor.authorYılmaz, A.
dc.contributor.authorBayrakçı, Nergiz
dc.contributor.authorGüzel, S.
dc.contributor.authorGeyik, E.
dc.date.accessioned2022-05-11T14:02:52Z
dc.date.available2022-05-11T14:02:52Z
dc.date.issued2021
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.description.abstractAim: MicroRNAs (miRNAs) are non-coding RNA molecules that serve as regulators following gene expression transcription. While studies have investigated the role of miRNAs in the pathogenesis of essential hypertension (HT), very few have considered their place in the pathogenesis of resistant hypertension (RH). The purpose of this study was to investigate levels of miRNA 21 and miRNA 155 in RH and their relationships with aldosterone. Method: Thirty-two normotensive patients, 30 newly diagnosed HT patients, and 20 RH patients were included in the study. Patients’ demographic data were recorded, and office blood pressure measurement and 24-h ambulatory blood pressure monitoring (24-h ABPM) were performed. Blood specimens were collected for miRNA 21, miRNA 155 and aldosterone measurement. MiRNA 21 and miRNA 155 levels in the control and patient groups and their relations with other demographic and biochemical parameters were then subjected to analysis. Results: No difference was determined in miRNA 155 levels between the groups, but miRNA 21 and aldosterone levels were significantly higher in the RH group (p < 0.001 and <0.05, respectively). At correlation analysis, miRNA 21 exhibited positive correlation with aldosterone, age, office SBP, 24-h ABPM all-day SBP. A 9.6 copy/uL level for miRNA 21 predicted presence or absence of RH with 95% sensitivity and 71% specificity (AUC:0.823, 95% CI (0.72–0.92). Conclusion: The study results revealed significantly higher miRNA 21 and aldosterone in RH patients than in healthy individuals and newly diagnosed hypertensives. © 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.
dc.description.sponsorshipThis study was supported by the Scientific Researches Fund of Tekirda? Nam?k Kemal University.
dc.identifier.doi10.1080/0886022X.2021.1915800
dc.identifier.endpage683
dc.identifier.issn0886-022X
dc.identifier.issue1en_US
dc.identifier.pmid33888045
dc.identifier.scopus2-s2.0-85105904549
dc.identifier.scopusqualityQ2
dc.identifier.startpage676
dc.identifier.urihttps://doi.org/10.1080/0886022X.2021.1915800
dc.identifier.urihttps://hdl.handle.net/20.500.11776/4518
dc.identifier.volume43
dc.identifier.wosWOS:000642485600001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorKara, Sonat Pınar
dc.institutionauthorÖzkan, Gülsüm
dc.institutionauthorYılmaz, A.
dc.institutionauthorBayrakçı, Nergiz
dc.institutionauthorGüzel, S.
dc.language.isoen
dc.publisherTaylor and Francis Ltd.
dc.relation.ispartofRenal Failure
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjecthypertension
dc.subjectmiRNA 155
dc.subjectmiRNA 21
dc.subjectResistant hypertension
dc.subjectaldosterone
dc.subjectmicroRNA 155
dc.subjectmicroRNA 21
dc.subjectaldosterone
dc.subjectmicroRNA
dc.subjectMIRN155 microRNA, human
dc.subjectMIRN21 microRNA, human
dc.subjectadult
dc.subjectaldosterone blood level
dc.subjectArticle
dc.subjectblood pressure measurement
dc.subjectblood pressure monitoring
dc.subjectclinical article
dc.subjectcontrolled study
dc.subjectessential hypertension
dc.subjectfemale
dc.subjectgene expression
dc.subjecthuman
dc.subjecthuman tissue
dc.subjecthypertensive patient
dc.subjectmale
dc.subjectmiddle aged
dc.subjectpriority journal
dc.subjectresistant hypertension
dc.subjectRNA blood level
dc.subjectsystolic blood pressure
dc.subjectaged
dc.subjectblood
dc.subjectcase control study
dc.subjectgenetics
dc.subjecthypertension
dc.subjectpathophysiology
dc.subjectAdult
dc.subjectAged
dc.subjectAldosterone
dc.subjectBlood Pressure Monitoring, Ambulatory
dc.subjectCase-Control Studies
dc.subjectFemale
dc.subjectHumans
dc.subjectHypertension
dc.subjectMale
dc.subjectMicroRNAs
dc.subjectMiddle Aged
dc.titleMicroRNA 21 and microRNA 155 levels in resistant hypertension, and their relationships with aldosterone
dc.typeArticle

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