MicroRNA 21 and microRNA 155 levels in resistant hypertension, and their relationships with aldosterone
Yükleniyor...
Dosyalar
Tarih
2021
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Taylor and Francis Ltd.
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Aim: MicroRNAs (miRNAs) are non-coding RNA molecules that serve as regulators following gene expression transcription. While studies have investigated the role of miRNAs in the pathogenesis of essential hypertension (HT), very few have considered their place in the pathogenesis of resistant hypertension (RH). The purpose of this study was to investigate levels of miRNA 21 and miRNA 155 in RH and their relationships with aldosterone. Method: Thirty-two normotensive patients, 30 newly diagnosed HT patients, and 20 RH patients were included in the study. Patients’ demographic data were recorded, and office blood pressure measurement and 24-h ambulatory blood pressure monitoring (24-h ABPM) were performed. Blood specimens were collected for miRNA 21, miRNA 155 and aldosterone measurement. MiRNA 21 and miRNA 155 levels in the control and patient groups and their relations with other demographic and biochemical parameters were then subjected to analysis. Results: No difference was determined in miRNA 155 levels between the groups, but miRNA 21 and aldosterone levels were significantly higher in the RH group (p < 0.001 and <0.05, respectively). At correlation analysis, miRNA 21 exhibited positive correlation with aldosterone, age, office SBP, 24-h ABPM all-day SBP. A 9.6 copy/uL level for miRNA 21 predicted presence or absence of RH with 95% sensitivity and 71% specificity (AUC:0.823, 95% CI (0.72–0.92). Conclusion: The study results revealed significantly higher miRNA 21 and aldosterone in RH patients than in healthy individuals and newly diagnosed hypertensives. © 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.
Açıklama
Anahtar Kelimeler
hypertension, miRNA 155, miRNA 21, Resistant hypertension, aldosterone, microRNA 155, microRNA 21, aldosterone, microRNA, MIRN155 microRNA, human, MIRN21 microRNA, human, adult, aldosterone blood level, Article, blood pressure measurement, blood pressure monitoring, clinical article, controlled study, essential hypertension, female, gene expression, human, human tissue, hypertensive patient, male, middle aged, priority journal, resistant hypertension, RNA blood level, systolic blood pressure, aged, blood, case control study, genetics, hypertension, pathophysiology, Adult, Aged, Aldosterone, Blood Pressure Monitoring, Ambulatory, Case-Control Studies, Female, Humans, Hypertension, Male, MicroRNAs, Middle Aged
Kaynak
Renal Failure
WoS Q Değeri
Q2
Scopus Q Değeri
Q2
Cilt
43
Sayı
1
