Effect of Lateralization on Motor and Mental Speed in Bipolar Disorder

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dc.authorid0000-0002-8514-0576
dc.authorid0000-0002-4431-3514
dc.authorscopusid54792689200
dc.authorscopusid23003686000
dc.authorscopusid36505421000
dc.authorscopusid6507010051
dc.authorscopusid55891366400
dc.authorwosidAtagun, Murat Ilhan/A-6386-2018
dc.contributor.authorAtagün, Murat İlhan
dc.contributor.authorBalaban, Özlem Devrim
dc.contributor.authorYeşilbaş, Dilek
dc.contributor.authorKeskinkilic, Cahit
dc.contributor.authorEvren, Cüneyt
dc.date.accessioned2022-05-11T14:41:02Z
dc.date.available2022-05-11T14:41:02Z
dc.date.issued2012
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Ruh Sağlığı ve Hastalıkları Ana Bilim Dalı
dc.description.abstractEffect of lateralization on motor and mental speed in bipolar disorder Objective: The correspondence between the motor and mood regulation systems may shed light on the physiopathology of mood disorders. Handedness is a reliable proxy measure for cerebral lateralization for right handed subjects. In this study we have investigated the effects of lateralization on cognitive performance as well as motor and mental speed in bipolar disorder. Methods: Sixty-eight euthymic bipolar patients (mean age: 33.66 +/- 6.38, 33 female), and 65 healthy subjects (mean age: 33.65+7.11, 27 females) were enrolled. Participants with medical or psychiatric comorbidities were excluded. The Montreal Cognitive Assessment (MOCA), finger-tapping, peg-board test, Adult Memory and Information Processing battery (AMIPB), Edinburgh Handedness Inventory and reaction time tests were the measures utilized in our study. Results: The groups were similar in terms of age, gender and education. The bipolar patients were more lateralized than the controls (p=0.027), whereas eye and foot lateralization did not differ between the groups. The patients performed poorer than the controls on the MOCA (p=0.049), peg-board (right and left, p<0.001), finger-tapping (right p<0.001; left p=0.002), AMIPB (motor and A subtest, p<0.001 for both) and the visual and auditory (p<0.001 for both) reaction time tests. The degree of lateralization was correlated with the speed of processing in the bipolar group, but not in the control group. Conclusion: Right handed patients with bipolar disorder are more lateralized than healthy subjects and lateralization provides an advantage for processing speed in bipolar patients. This finding may indicate a relationship between lateralizing physiopathology and slowed interhemispheric communication and thus, an increase in lateralization might be a compensatory mechanism to use less interhemispheric communication in bipolar disorder.
dc.identifier.doi10.5455/bcp.20120827114812
dc.identifier.endpage306
dc.identifier.issn1017-7833
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-84869772581
dc.identifier.scopusqualityN/A
dc.identifier.startpage297
dc.identifier.urihttps://doi.org/10.5455/bcp.20120827114812
dc.identifier.urihttps://hdl.handle.net/20.500.11776/9034
dc.identifier.volume22
dc.identifier.wosWOS:000313460800002
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorAtagün, Murat İlhan
dc.language.isoen
dc.publisherKure Iletisim Grubu A S
dc.relation.ispartofKlinik Psikofarmakoloji Bulteni-Bulletin of Clinical Psychopharmacology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectBipolar disorder
dc.subjecthandedness
dc.subjectcerebral hemispheres
dc.subjecthuman information processing
dc.subjectMontreal Cognitive Assessment
dc.subjectPrefrontal Cortex
dc.subjectEuthymic Patients
dc.subjectCorpus-Callosum
dc.subjectBasal Ganglia
dc.subjectRating-Scale
dc.subjectSchizophrenia
dc.subjectHandedness
dc.subjectAsymmetry
dc.subjectMetaanalysis
dc.titleEffect of Lateralization on Motor and Mental Speed in Bipolar Disorder
dc.title.alternativeBipolar bozuklukta lateralizasyonun motor ve mental hıza etkisi]
dc.typeArticle

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