Evaluation of Paraoxonase and Arylesterase activities in patients with irritable bowel syndrome

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dc.authorscopusid55881189500
dc.authorscopusid8514414100
dc.authorscopusid36608599700
dc.authorscopusid7102765266
dc.authorscopusid56239540000
dc.authorscopusid36866111300
dc.contributor.authorOran, Mustafa
dc.contributor.authorTülübaş, Feti
dc.contributor.authorMete, Rafet
dc.contributor.authorAydın, Murat
dc.contributor.authorSarıkaya, Hatice Gul
dc.contributor.authorGürel, Ahmet
dc.date.accessioned2022-05-11T14:10:00Z
dc.date.available2022-05-11T14:10:00Z
dc.date.issued2014
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Anesteziyoloji ve Reanimasyon Ana Bilim Dalı
dc.description.abstractThe aims of the present study were to evaluate oxidative status, by investigating the serum Paraoxonase/Arylesterase (PON/ARE) activities along with conjugated dienes in patients with IBS and controls and to confirm the link between oxidative stress and IBS. Thirty IBS patient and 30 healthy subjects were recruited. Total serum cholesterol, low-density lipoprotein (LDL), high-density lipoprotein (HDL), triglycerides (TG), PON and ARE activities and conjugated dienes levels were measured. Mean serum PON1 activity was lower in IBS group compared to that of the control group whereas there was no significant difference in ARE activity between IBS and control groups (p<0.000, p<0.716, respectively). Serum conjugated diene levels of the IBS group was significantly higher than that of the control group (p<0.01). The drop in PON activity accompanied with an increase in conjugated diene levels indicate the presence of oxidative stress, a disturbance in prooxidant - antioxidant balance and increased inflammation in IBS patients.
dc.identifier.endpage822
dc.identifier.issn0030-9982
dc.identifier.issue7en_US
dc.identifier.pmid25255593
dc.identifier.scopus2-s2.0-84903525518
dc.identifier.scopusqualityQ4
dc.identifier.startpage820
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5241
dc.identifier.volume64
dc.identifier.wosWOS:000337768600019
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorOran, Mustafa
dc.institutionauthorTülübaş, Feti
dc.institutionauthorMete, Rafet
dc.institutionauthorAydın, Murat
dc.institutionauthorSarıkaya, Hatice Gul
dc.institutionauthorGürel, Ahmet
dc.language.isoen
dc.publisherPakistan Medical Assoc
dc.relation.ispartofJournal of the Pakistan Medical Association
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectIBS
dc.subjectPON1
dc.subjectARE
dc.subjectConjugated Diene
dc.subjectPermeability
dc.subjectInflammation
dc.subjectDiseases
dc.titleEvaluation of Paraoxonase and Arylesterase activities in patients with irritable bowel syndrome
dc.typeArticle

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