Evaluation of Paraoxonase and Arylesterase activities in patients with irritable bowel syndrome
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Dosyalar
Tarih
2014
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Pakistan Medical Assoc
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The aims of the present study were to evaluate oxidative status, by investigating the serum Paraoxonase/Arylesterase (PON/ARE) activities along with conjugated dienes in patients with IBS and controls and to confirm the link between oxidative stress and IBS. Thirty IBS patient and 30 healthy subjects were recruited. Total serum cholesterol, low-density lipoprotein (LDL), high-density lipoprotein (HDL), triglycerides (TG), PON and ARE activities and conjugated dienes levels were measured. Mean serum PON1 activity was lower in IBS group compared to that of the control group whereas there was no significant difference in ARE activity between IBS and control groups (p<0.000, p<0.716, respectively). Serum conjugated diene levels of the IBS group was significantly higher than that of the control group (p<0.01). The drop in PON activity accompanied with an increase in conjugated diene levels indicate the presence of oxidative stress, a disturbance in prooxidant - antioxidant balance and increased inflammation in IBS patients.
Açıklama
Anahtar Kelimeler
IBS, PON1, ARE, Conjugated Diene, Permeability, Inflammation, Diseases
Kaynak
Journal of the Pakistan Medical Association
WoS Q Değeri
Q4
Scopus Q Değeri
Q4
Cilt
64
Sayı
7
