Carbonic anhydrase I and II autoantibody levels in primary hypertension: Our preliminary results

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dc.authorscopusid57221503673
dc.authorscopusid8570900600
dc.authorscopusid57203191079
dc.authorscopusid23489347700
dc.authorscopusid55674801800
dc.authorscopusid6603926071
dc.contributor.authorKara, Sonat Pınar
dc.contributor.authorÖzkan, Gülsüm
dc.contributor.authorEmeksiz, Kübra
dc.contributor.authorMenteşe, A.
dc.contributor.authorDemir, S.
dc.contributor.authorUlusoy, S.
dc.date.accessioned2022-05-11T14:05:02Z
dc.date.available2022-05-11T14:05:02Z
dc.date.issued2021
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.description.abstractOBJECTIVE: The pathogenesis of primary hypertension (HT) is still not completely clear, although autoimmunity has been implicated in recent years. Carbonic anhydrase (CA) is an enzyme involved in a number of important metabolic processes. CA I and II autoantibodies have been linked to various autoimmune diseases. However, CA I and II autoantibody levels in primary HT have not been previously investigated. The purpose of this study was, therefore, to investigate levels of CA I and II autoantibodies in primary HT. PATIENTS AND METHODS: Fifty-six patients newly diagnosed with primary HT and 33 healthy individuals were included in the study. Twenty- four-hour ambulatory blood pressure monitoring was performed following office controls. Blood specimens were collected under appropriate conditions for CA I and II autoantibody level investigation and biochemical tests. Urine sodium and protein excretion were measured after 24 h. Demographic and biochemical parameters and CA I and II autoantibody levels were then compared between the patient and healthy groups. RESULTS: CA II autoantibody and uric acid levels were significantly higher in the hypertensive group than in the control group (p=0.005, and p<0.001, respectively). CA II autoantibody (exp ß: 79.06 CI: 4.44-1407.02) (p=0.003) and uric acid elevation (exp ß: 2.10 CI: 1.31- 3.34) (p=0.002) were identified as independent predictors of HT development at logistic regression analysis. CONCLUSIONS: CA II autoantibody levels were higher in hypertensive patients, and this elevation is an independent predictor of HT development. © 2020 Verduci Editore s.r.l. All rights reserved.
dc.identifier.doi10.26355/eurrev_202012_24183
dc.identifier.endpage12826
dc.identifier.issn1128-3602
dc.identifier.issue24en_US
dc.identifier.pmid33378031
dc.identifier.scopus2-s2.0-85099321451
dc.identifier.scopusqualityQ2
dc.identifier.startpage12821
dc.identifier.urihttps://doi.org/10.26355/eurrev_202012_24183
dc.identifier.urihttps://hdl.handle.net/20.500.11776/4874
dc.identifier.volume25
dc.identifier.wosWOS:000601364400044
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorÖzkan, Gülsüm
dc.language.isoen
dc.publisherVerduci Editore s.r.l
dc.relation.ispartofEuropean Review for Medical and Pharmacological Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCA
dc.subjectCA I autoantibody
dc.subjectCA II autoantibody
dc.subjectCarbonic anhydrase
dc.subjectHypertension
dc.subjectautoantibody
dc.subjectcarbonate dehydratase I
dc.subjectcarbonate dehydratase II
dc.subjectautoantibody
dc.subjectsodium
dc.subjectautoantibody
dc.subjectcarbonate dehydratase I
dc.subjectcarbonate dehydratase II
dc.subjectadult
dc.subjectantibody blood level
dc.subjectantibody detection
dc.subjectArticle
dc.subjectbody mass
dc.subjectcontrolled study
dc.subjectenzyme blood level
dc.subjectessential hypertension
dc.subjectfemale
dc.subjecthuman
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectpredictive value
dc.subjectprotein function
dc.subjectsodium urine level
dc.subjectbiochemistry
dc.subjectblood analysis
dc.subjectblood pressure monitoring
dc.subjectdemography
dc.subjectenzymuria
dc.subjectessential hypertension
dc.subjectindependent variable
dc.subjectpathogenesis
dc.subjectpredictor variable
dc.subjectblood
dc.subjecthypertension
dc.subjectmetabolism
dc.subjectmiddle aged
dc.subjectAutoantibodies
dc.subjectCarbonic Anhydrase I
dc.subjectCarbonic Anhydrase II
dc.subjectFemale
dc.subjectHumans
dc.subjectHypertension
dc.subjectMale
dc.subjectMiddle Aged
dc.titleCarbonic anhydrase I and II autoantibody levels in primary hypertension: Our preliminary results
dc.typeArticle

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