Carbonic anhydrase I and II autoantibody levels in primary hypertension: Our preliminary results
Yükleniyor...
Dosyalar
Tarih
2021
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Verduci Editore s.r.l
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
OBJECTIVE: The pathogenesis of primary hypertension (HT) is still not completely clear, although autoimmunity has been implicated in recent years. Carbonic anhydrase (CA) is an enzyme involved in a number of important metabolic processes. CA I and II autoantibodies have been linked to various autoimmune diseases. However, CA I and II autoantibody levels in primary HT have not been previously investigated. The purpose of this study was, therefore, to investigate levels of CA I and II autoantibodies in primary HT. PATIENTS AND METHODS: Fifty-six patients newly diagnosed with primary HT and 33 healthy individuals were included in the study. Twenty- four-hour ambulatory blood pressure monitoring was performed following office controls. Blood specimens were collected under appropriate conditions for CA I and II autoantibody level investigation and biochemical tests. Urine sodium and protein excretion were measured after 24 h. Demographic and biochemical parameters and CA I and II autoantibody levels were then compared between the patient and healthy groups. RESULTS: CA II autoantibody and uric acid levels were significantly higher in the hypertensive group than in the control group (p=0.005, and p<0.001, respectively). CA II autoantibody (exp ß: 79.06 CI: 4.44-1407.02) (p=0.003) and uric acid elevation (exp ß: 2.10 CI: 1.31- 3.34) (p=0.002) were identified as independent predictors of HT development at logistic regression analysis. CONCLUSIONS: CA II autoantibody levels were higher in hypertensive patients, and this elevation is an independent predictor of HT development. © 2020 Verduci Editore s.r.l. All rights reserved.
Açıklama
Anahtar Kelimeler
CA, CA I autoantibody, CA II autoantibody, Carbonic anhydrase, Hypertension, autoantibody, carbonate dehydratase I, carbonate dehydratase II, autoantibody, sodium, autoantibody, carbonate dehydratase I, carbonate dehydratase II, adult, antibody blood level, antibody detection, Article, body mass, controlled study, enzyme blood level, essential hypertension, female, human, major clinical study, male, predictive value, protein function, sodium urine level, biochemistry, blood analysis, blood pressure monitoring, demography, enzymuria, essential hypertension, independent variable, pathogenesis, predictor variable, blood, hypertension, metabolism, middle aged, Autoantibodies, Carbonic Anhydrase I, Carbonic Anhydrase II, Female, Humans, Hypertension, Male, Middle Aged
Kaynak
European Review for Medical and Pharmacological Sciences
WoS Q Değeri
Q2
Scopus Q Değeri
Q2
Cilt
25
Sayı
24
