Royal jelly attenuates gastric mucosal injury in a rat ethanol-induced gastric injury model

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dc.authorscopusid57212512972
dc.authorscopusid55838809000
dc.authorscopusid8855691800
dc.authorscopusid56727936300
dc.authorscopusid56816914100
dc.authorscopusid55897728300
dc.authorscopusid57191922068
dc.contributor.authorDuran, Y.
dc.contributor.authorKaraboğa, İhsan
dc.contributor.authorPolat, Fatin Rüştü
dc.contributor.authorPolat, E.
dc.contributor.authorErboğa, Zeynep Fidanol
dc.contributor.authorOvalı, M. A.
dc.contributor.authorYılmaz, A.
dc.contributor.authorÇelikkol, A.
dc.date.accessioned2022-05-11T14:01:33Z
dc.date.available2022-05-11T14:01:33Z
dc.date.issued2020
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Genel Cerrahi Ana Bilim Dalı
dc.departmentYüksekokullar, Sağlık Yüksekokulu, Acil Yardım ve Afet Yönetimi Bölümü
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Mikrobiyoloji Ana Bilim Dalı
dc.description.abstractThe aim of the study was to investigate traditionally used Royal Jelly (RJ) for treating an ethanol-induced gastric ulcer model in rats. A total of 32 Wistar albino male rats were divided into 4 groups of 8: group I = Control, group II = Ethanol, group III = RJ + Ethanol, and group IV = Lansoprazole + Ethanol. In groups II, III, and IV, animals were administered 1 ml of absolute ethanol orally after a 24-h fast to induce ulcer formation. The histopathological changes in the gastric mucosa were determined using hematoxylin-eosin (H&E) staining. Immunohistochemically, inducible nitric oxide (iNOS) and nuclear factor kappa beta (Nf-??) markings were evaluated in gastric tissue. Cell death in the gastric mucosa was determined by the TUNEL method. Oxidative status markers, superoxide dismutase (SOD), malondialdehyde (MDA), catalase (CAT), and myeloperoxidase (MPO) levels were determined spectrophotometrically. Expression of the interleukin – 1 beta (IL-1?) and tumor necrosis factor-? (TNF-?) genes in gastric tissues was determined by real-time PCR; and TNF-?, IL-10, and IL-1? levels were determined. RJ was found to inhibit iNOS and Nf-?? activity in the gastric mucosa and prevent epithelial cell apoptosis. In particular, pro-inflammatory cytokines TNF-? and IL-1? levels were significantly decreased in the RJ + Ethanol group compared to the Ethanol group. In addition, a decrease in the MPO level indicated that RJ prevented tissue damage, especially by preventing inflammatory cell infiltration. The study demonstrated a possible gastroprotective effect of RJ in a rat ethanol-induced gastric ulcer model. © 2020, Springer Nature B.V.
dc.description.sponsorshipThis work was supported by the Research Fund of the Tekirda? Nam?k Kemal University. Project Number: NKUBAP.02.GA.18.181.
dc.description.sponsorshipThis work was supported by the Research Fund of the Tekirdağ Namık Kemal University. Project Number: NKUBAP.02.GA.18.181.
dc.identifier.doi10.1007/s11033-020-05939-w
dc.identifier.endpage8879
dc.identifier.issn0301-4851
dc.identifier.issue11en_US
dc.identifier.pmid33135128
dc.identifier.scopus2-s2.0-85094844653
dc.identifier.scopusqualityQ2
dc.identifier.startpage8867
dc.identifier.urihttps://doi.org/10.1007/s11033-020-05939-w
dc.identifier.urihttps://hdl.handle.net/20.500.11776/4434
dc.identifier.volume47
dc.identifier.wosWOS:000584364400002
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorDuran, Y.
dc.institutionauthorKaraboğa, İhsan
dc.institutionauthorPolat, Fatin Rüştü
dc.institutionauthorPolat, E.
dc.institutionauthorErboğa, Zeynep Fidanol
dc.institutionauthorOvalı, M. A.
dc.institutionauthorYılmaz, A.
dc.institutionauthorÇelikkol, A.
dc.language.isoen
dc.publisherSpringer Science and Business Media B.V.
dc.relation.ispartofMolecular Biology Reports
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectApoptosis
dc.subjectGastric ulcer
dc.subjectInducible nitric oxide synthase
dc.subjectNuclear factor-kappa beta
dc.subjectRoyal Jelly
dc.subjectcatalase
dc.subjectimmunoglobulin enhancer binding protein
dc.subjectinducible nitric oxide synthase
dc.subjectinterleukin 10
dc.subjectinterleukin 1beta
dc.subjectlansoprazole
dc.subjectmalonaldehyde
dc.subjectmyeloperoxidase
dc.subjectroyal jelly
dc.subjectsuperoxide dismutase
dc.subjecttumor necrosis factor
dc.subjectalcohol
dc.subjectcatalase
dc.subjectcentral depressant agent
dc.subjectcytokine
dc.subjectfatty acid
dc.subjectimmunoglobulin enhancer binding protein
dc.subjectmalonaldehyde
dc.subjectroyal jelly
dc.subjectsuperoxide dismutase
dc.subjectadult
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectapoptosis
dc.subjectArticle
dc.subjectcell death
dc.subjectcontrolled study
dc.subjectenzyme activity
dc.subjectenzyme linked immunosorbent assay
dc.subjectepithelium cell
dc.subjectethanol-induced gastric ulcer
dc.subjectgene expression
dc.subjecthematoxylin eosin staining
dc.subjecthistopathology
dc.subjectIL 1beta gene
dc.subjectimmunohistochemistry
dc.subjectmale
dc.subjectnonhuman
dc.subjectprotein blood level
dc.subjectprotein expression
dc.subjectrat
dc.subjectreal time polymerase chain reaction
dc.subjectspectrophotometry
dc.subjectstaining
dc.subjectstomach protection
dc.subjectTNF alpha gene
dc.subjecttranscription initiation
dc.subjectTUNEL assay
dc.subjectWistar rat
dc.subjectanimal
dc.subjectdisease model
dc.subjectdrug effect
dc.subjectgenetics
dc.subjectinjury
dc.subjectmetabolism
dc.subjectoxidative stress
dc.subjectstomach mucosa
dc.subjectstomach ulcer
dc.subjectAnimals
dc.subjectApoptosis
dc.subjectCatalase
dc.subjectCentral Nervous System Depressants
dc.subjectCytokines
dc.subjectDisease Models, Animal
dc.subjectEthanol
dc.subjectFatty Acids
dc.subjectGastric Mucosa
dc.subjectGene Expression
dc.subjectMale
dc.subjectMalondialdehyde
dc.subjectNF-kappa B
dc.subjectOxidative Stress
dc.subjectRats, Wistar
dc.subjectStomach Ulcer
dc.subjectSuperoxide Dismutase
dc.titleRoyal jelly attenuates gastric mucosal injury in a rat ethanol-induced gastric injury model
dc.typeArticle

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