Canine Saliva as a Possible Source of Antimicrobial Resistance Genes

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dc.authoridKAPLAN, SELCUK/0000-0003-1101-2296
dc.authoridSolymosi, Norbert/0000-0003-1783-2041
dc.authorwosidKaplan, Selçuk/ABA-2299-2020
dc.contributor.authorToth, Adrienn Greta
dc.contributor.authorToth, İmre
dc.contributor.authorRozsa, Bernadett
dc.contributor.authorDubecz, Attila
dc.contributor.authorPatai, Arpad, V
dc.contributor.authorNemeth, Tibor
dc.contributor.authorKaplan, Selçuk
dc.date.accessioned2023-05-06T17:23:40Z
dc.date.available2023-05-06T17:23:40Z
dc.date.issued2022
dc.departmentFakülteler, Ziraat Fakültesi, Tarımsal Biyoteknoloji Bölümü
dc.description.abstractWhile the One Health issues of intensive animal farming are commonly discussed, keeping companion animals is less associated with the interspecies headway of antimicrobial resistance. With the constant advance in veterinary standards, antibiotics are regularly applied in companion animal medicine. Due to the close coexistence of dogs and humans, dog bites and other casual encounters with dog saliva (e.g., licking the owner) are common. According to our metagenome study, based on 26 new generation sequencing canine saliva datasets from 2020 and 2021 reposited in NCBI SRA by The 10,000 Dog Genome Consortium and the Broad Institute within Darwin's Ark project, canine saliva is rich in bacteria with predictably transferable antimicrobial resistance genes (ARGs). In the genome of potentially pathogenic Bacteroides, Capnocytophaga, Corynebacterium, Fusobacterium, Pasteurella, Porphyromonas, Staphylococcus and Streptococcus species, which are some of the most relevant bacteria in dog bite infections, ARGs against aminoglycosides, carbapenems, cephalosporins, glycylcyclines, lincosamides, macrolides, oxazolidinone, penams, phenicols, pleuromutilins, streptogramins, sulfonamides and tetracyclines could be identified. Several ARGs, including ones against amoxicillin-clavulanate, the most commonly applied antimicrobial agent for dog bites, were predicted to be potentially transferable based on their association with mobile genetic elements (e.g., plasmids, prophages and integrated mobile genetic elements). According to our findings, canine saliva may be a source of transfer for ARG-rich bacteria that can either colonize the human body or transport ARGs to the host bacteriota, and thus can be considered as a risk in the spread of antimicrobial resistance.
dc.description.sponsorshipEuropean Union's Horizon 2020 research and innovation program [874735]
dc.description.sponsorshipThe research was supported by the European Union's Horizon 2020 research and innovation program under Grant Agreement No. 874735 (VEO).
dc.identifier.doi10.3390/antibiotics11111490
dc.identifier.issn2079-6382
dc.identifier.issue11en_US
dc.identifier.pmid36358144
dc.identifier.scopus2-s2.0-85141752555
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.3390/antibiotics11111490
dc.identifier.urihttps://hdl.handle.net/20.500.11776/12240
dc.identifier.volume11
dc.identifier.wosWOS:000880709100001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorKaplan, Selçuk
dc.language.isoen
dc.publisherMdpi
dc.relation.ispartofAntibiotics-Basel
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectantimicrobial resistance
dc.subjectbacteriome
dc.subjectresistome
dc.subjectmobilome
dc.subjectdog saliva
dc.subjectDog Bites
dc.subjectPrescribing Patterns
dc.subjectMicrobiology
dc.subjectPrescription
dc.subjectPopulation
dc.subjectManagement
dc.subjectReservoirs
dc.subjectInfection
dc.subjectTrends
dc.subjectCats
dc.titleCanine Saliva as a Possible Source of Antimicrobial Resistance Genes
dc.typeArticle

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