Impact of glucocorticoid receptor gene (NR3C1) polymorphisms in Turkish patients with metabolic syndrome

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dc.authorid0000-0001-6222-7882
dc.authorid0000-0002-1100-765X
dc.authorid0000-0002-1100-765X
dc.authorid0000-0002-6044-1372
dc.authorscopusid55876457500
dc.authorscopusid7006479102
dc.authorscopusid57195257114
dc.authorscopusid6602491471
dc.authorscopusid6602211238
dc.authorscopusid7006536069
dc.authorscopusid7005139386
dc.authorwosidKaya, Zehra/AAE-8135-2020
dc.authorwosidAkkiprik, Mustafa/A-6453-2017
dc.authorwosidAkkiprik, Mustafa/AAD-6167-2020
dc.contributor.authorKaya, Zeki
dc.contributor.authorÇaglayan, S.
dc.contributor.authorAkkiprik, Mustafa
dc.contributor.authorAral, Cenk
dc.contributor.authorÖzışık, Gökhan
dc.contributor.authorÖzata, M.
dc.contributor.authorÖzer, A.
dc.date.accessioned2022-05-11T14:28:33Z
dc.date.available2022-05-11T14:28:33Z
dc.date.issued2016
dc.departmentFakülteler, Fen Edebiyat Fakültesi, Biyoloji Bölümü
dc.description.abstractBackground The metabolic syndrome (MetS) is characterized by a cluster of metabolic factors, including insulin resistance and type-2 diabetes, abdominal obesity, dyslipidemia, hypertension and microalbuminuria. Impaired glucocorticoid receptor (GR) activity also plays an important role in the etiology of MetS. The objective of our study is to evaluate the effects of GR gene polymorphisms (BclI, N363S, TthIII1 and ER22/23EK) in Turkish patients with MetS. Materials and methods Seventy subjects with MetS and 185 healthy controls were enrolled in the study. PCR-RFLP analysis was used for genotyping. Results for each polymorphism have been verified by allele-specific oligonucleotide analysis. Results BclI GG genotype was significantly associated with an increased risk of MetS (p = 0.02). Also, only in women, the G allele carriers were significantly associated with higher C-peptide. T allele carriers of TthIII1 polymorphism were significantly associated with higher C-peptide, triglyceride, insulin and C-reactive protein (CRP, p value 0.048, 0.022, 0.005 and 0.022, respectively), and lower fasting blood glucose (FBG, p = 0.02). The combined carriers of BclI polymorphism G allele and TthIII1 polymorphism T allele were significantly associated with higher diastolic blood pressure in all patients, and lower FBG and postprandial blood glucose in only men. All the ER22/23EK polymorphisms coexisted with polymorphic variant of TthIII1 (p = 0.0058). Conclusion The presence of homozygote polymorphic variant of BclI might be good predictive markers for the disease susceptibility. The BclI and the TthIII1 polymorphism are associated with sex-specific clinical parameters. Our findings also suggest that the combination of BclI and TthIII1 polymorphisms may play a protective role in blood glucose.
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [104S272, SBAG-K-60]; Research Foundation of Marmara University (BAPKO)Marmara University [SAG-C-DRP-101011-0286]
dc.description.sponsorshipThe authors appreciate Dr. Can Erzik for his critical revision of the manuscript. This work was partly supported by a grant (104S272, SBAG-K-60 to SC) from the Scientific and Technological Research Council of Turkey (TUBITAK) and grants (SAG-C-DRP-101011-0286 to AO) from the Research Foundation of Marmara University (BAPKO).
dc.identifier.doi10.1007/s40618-015-0409-1
dc.identifier.endpage566
dc.identifier.issn1720-8386
dc.identifier.issue5en_US
dc.identifier.pmid26596278
dc.identifier.scopus2-s2.0-84964329103
dc.identifier.scopusqualityQ2
dc.identifier.startpage557
dc.identifier.urihttps://doi.org/10.1007/s40618-015-0409-1
dc.identifier.urihttps://hdl.handle.net/20.500.11776/6871
dc.identifier.volume39
dc.identifier.wosWOS:000374102700010
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAral, Cenk
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofJournal of Endocrinological Investigation
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectMetabolic syndrome
dc.subjectGlucocorticoid receptor gene
dc.subjectGlucocorticoid
dc.subjectC-Reactive Protein
dc.subjectFragment-Length-Polymorphism
dc.subjectPituitary-Adrenal Axis
dc.subjectIn-Vivo
dc.subjectChinese Population
dc.subjectAssociation
dc.subjectSensitivity
dc.subjectStress
dc.subjectRisk
dc.subjectBcli
dc.titleImpact of glucocorticoid receptor gene (NR3C1) polymorphisms in Turkish patients with metabolic syndrome
dc.typeArticle

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