Characterization and Lidocaine Release Behavior of Chitosan/ Sodium Alginate/ Clinoptiolite Nanocomposite Hydrogel

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dc.contributor.authorSözkes, Sarkis
dc.contributor.authorTaşdelen, Betül
dc.contributor.authorErdoğan, Sevil
dc.contributor.authorGülenç, Nadide Gülşah
dc.contributor.authorKoruyucu, Aslıhan
dc.date.accessioned2025-04-06T12:21:57Z
dc.date.available2025-04-06T12:21:57Z
dc.date.issued2024
dc.departmentTekirdağ Namık Kemal Üniversitesi
dc.description.abstractIn this study, the novel nanocomposites were prepared from the natural biopolymers, chitosan (CS), sodium alginate (SA) and clinoptiolite (CL) particles, and also having glutaraldehyde as a crosslinker by cryogelation technique. CS biopolymer was produced from crayfish Astacus leptodactylus Eschscholtz, 1823. Characterization of the prepared CS, CS-co-SA (CS/SA) and drug loaded CS/SA/ CL nanocomposite were performed by Fourier Transform Infrared Spectroscopy (FTIR) and Scanning Electron Microscopy (SEM) analyses. The anesthetic drug release behavior of the prepared nanocomposite was investigated for the model drug lidocaine (LD) using UV-Vis spectrophotometry and High Performance Liquid Chromatography (HPLC) techniques. The effect of different LD and CL content on the drug release behavior of the prepared nanocomposite were studied. LD release data was fitted to various kinetic models to study the drug release behavior. The LD release from all the prepared nanocomposite hydrogels fitted zero-order, first-order, Higuchi, and Korsmeyer-Peppas models. The swelling and drug release properties of the new CS-based nanocomposite hydrogels were improved with the inclusion of SA and CL in the gel structure. © 2024, Turkish Chemical Society. All rights reserved.
dc.description.sponsorshipTekirdağ Namık Kemal Üniversitesi, TNKU, (21.330)
dc.description.sponsorshipTekirdağ Namık Kemal Üniversitesi, TNKU
dc.identifier.doi10.18596/jotcsa.1440521
dc.identifier.endpage1494
dc.identifier.issn2149-0120
dc.identifier.issue4
dc.identifier.scopus2-s2.0-85211762650
dc.identifier.scopusqualityQ3
dc.identifier.startpage1483
dc.identifier.trdizinid1288702
dc.identifier.urihttps://doi.org/10.18596/jotcsa.1440521
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1288702
dc.identifier.urihttps://hdl.handle.net/20.500.11776/17044
dc.identifier.volume11
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTr-Dizin
dc.language.isoen
dc.publisherTurkish Chemical Society
dc.relation.ispartofJournal of the Turkish Chemical Society, Section A: Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_Scopus_20250406
dc.subjectChitosan
dc.subjectClinoptiolite
dc.subjectDrug Release
dc.subjectLidocaine
dc.subjectSodium alginate
dc.titleCharacterization and Lidocaine Release Behavior of Chitosan/ Sodium Alginate/ Clinoptiolite Nanocomposite Hydrogel
dc.typeArticle

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