Interaction of antimony(III) chloride with thiourea, 2-mercapto-5-methyl-benzimidazole, 3-methyl-2-mercaptobenzothiazole, 2-mercaptopyrimidine, and 2-mercaptopyridine

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dc.authorid0000-0003-3164-0038
dc.authorid0000-0003-3264-2406
dc.authorid0000-0001-7645-5560
dc.authorid0000-0001-9556-6266
dc.authorid0000-0002-4804-3822
dc.authorscopusid36785856200
dc.authorscopusid6507202525
dc.authorscopusid6602925165
dc.authorscopusid56884173600
dc.authorscopusid6602706096
dc.authorscopusid35517390800
dc.authorscopusid36049696300
dc.authorwosidOzturk, Ibrahim Ismet/K-1352-2013
dc.authorwosidKourkoumelis, Nikolaos/B-8555-2009
dc.authorwosidManos, Emmanouil/F-3442-2014
dc.authorwosidManos, Emmanouil/F-8887-2012
dc.authorwosidHadjikakou, Sotiris K./I-2909-2019
dc.authorwosidButler, Ian/AAI-7026-2021
dc.contributor.authorÖztürk, İbrahim İsmet
dc.contributor.authorKourkoumelis, Nikolaos
dc.contributor.authorHadjikakou, Sotiris K.
dc.contributor.authorManos, Manolis
dc.contributor.authorTasiopoulos, Anastasios J.
dc.contributor.authorButler, Ian
dc.contributor.authorHadjiliadis, Nick
dc.date.accessioned2022-05-11T14:29:45Z
dc.date.available2022-05-11T14:29:45Z
dc.date.issued2011
dc.departmentFakülteler, Fen Edebiyat Fakültesi, Kimya Bölümü
dc.description.abstractNew antimony(III) chloride complexes with heterocyclic thioamides, thiourea (TU), 2-mercapto-5-methyl-benzimidazole (MMBZIM), 3-methyl-2-mercaptobenzothiazole (MMBZT), 2-mercaptopyrimidine (PMT), 2-mercaptopyridine (PYT) of formulae [SbCl3(TU)(2)] (1), [SbCl3(MMBZIM)(2)] (2), [SbCl3(MMBZT)(2)] (3), [SbCl3(PMT)(2)] (4), [SbCl3(mu(2)-S)(PYT)(2)] (5) were synthesized and characterized by elemental analysis, FT-IR and FT-Raman spectroscopies, and TG-DTA analysis. The crystal structure of 5 was also determined by X-ray diffraction. [C10H10Cl3N2S2Sb] (5) crystallizes in space group C2/c, with a = 25.0169(10) angstrom, b = 9.7952(3) angstrom, c = 12.9329(5) angstrom, beta = 109.702(4)degrees, and Z = 8. Crystals of 5 grown from acetonitrile solutions adopt a square-pyramidal geometry. The equatorial plane is formed by three chlorides and one sulfur atom from the thione ligand while the second sulfur is axial. The complexes were evaluated for their biological activities and compared with [SbCl3(MMI)(2)] (6) (MMI = 2-mercapto-1-methylimidazole) and other isostructural ones. The complexes showed moderate cytostatic activity against murine leukemia cells (L1210), murine mammary carcinoma cells (FM3A), human T-lymphocyte (Molt4/C8, CEM), and human cervix carcinoma (HeLa) cells. The chloro and iodo derivatives show better cytostatic activity than the bromo ones.
dc.description.sponsorshipHellenic Ministry of Education; NATONATO (North Atlantic Treaty Organisation) [PDD(CP)-(CBP.NR.NRCLG 983167)]
dc.description.sponsorshipThis research was carried out in partial fulfillment of the requirements for the PhD thesis of I.I.O., under the supervision of S. K. H., under the framework of the graduate program in Bioinorganic Chemistry, coordinated by N.H., at the University of Ioannina. S.K.H., N.H., and I.S.B. would like to acknowledge a NATO grant for the exchange of scientists (PDD(CP)-(CBP.NR.NRCLG 983167). I.I.O. thanks the Hellenic Ministry of Education for a scholarship for postgraduate studies.
dc.identifier.doi10.1080/00958972.2011.633603
dc.identifier.endpage3871
dc.identifier.issn0095-8972
dc.identifier.issn1029-0389
dc.identifier.issue22en_US
dc.identifier.scopus2-s2.0-84855768225
dc.identifier.scopusqualityQ3
dc.identifier.startpage3859
dc.identifier.urihttps://doi.org/10.1080/00958972.2011.633603
dc.identifier.urihttps://hdl.handle.net/20.500.11776/7120
dc.identifier.volume64
dc.identifier.wosWOS:000299471200002
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorÖztürk, İbrahim İsmet
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofJournal of Coordination Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectBioinorganic chemistry
dc.subjectAntimony(III) chloride complexes
dc.subjectThioamides
dc.subjectCrystal structure
dc.subjectCytotoxic activity
dc.subjectCrystal-Structure
dc.subjectIn-Vitro
dc.subjectDiphenylantimony(Iii) Derivatives
dc.subjectStructural-Characterization
dc.subjectMolecular-Structure
dc.subjectX-Ray
dc.subjectComplexes
dc.subjectSpectroscopy
dc.subjectThioamides
dc.subjectDensity
dc.titleInteraction of antimony(III) chloride with thiourea, 2-mercapto-5-methyl-benzimidazole, 3-methyl-2-mercaptobenzothiazole, 2-mercaptopyrimidine, and 2-mercaptopyridine
dc.typeArticle

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