The effects of Spirulina platensis (Arthrospira platensis) and Saccharomyces cerevisiae on the distribution and cytokine production of CD4+and CD8+T-lymphocytes in rabbits

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dc.authorid0000-0002-2817-5131
dc.authorscopusid55921065100
dc.authorscopusid6603186991
dc.authorscopusid6701913697
dc.authorscopusid55347697800
dc.authorwosidBudak, Ferah/F-4657-2014
dc.authorwosidSeyidoglu, Nilay/AAS-2344-2020
dc.contributor.authorSeyidoğlu, Nilay
dc.contributor.authorGalip, Nurten
dc.contributor.authorBudak, Ferah
dc.contributor.authorUzabacı, Ender
dc.date.accessioned2022-05-11T14:42:26Z
dc.date.available2022-05-11T14:42:26Z
dc.date.issued2017
dc.departmentFakülteler, Veteriner Fakültesi, Temel Bilimler Bölümü, Fizyoloji Ana Bilim Dalı
dc.description.abstractNatural additives have become one of the most alternative immune enhancer nowadays. In particular, Spirulina platensis (Arthrospira platensis) (SP) and Saccharomyces cerevisiae (SC) have been used for improving the immune system and quality of life. The aim of this study was to regulate the immune effect of S. cerevisiae and S. platensis (A. platensis) combination. Forty male New Zealand white rabbits, aged 5-6 weeks, were analysed in 4 groups: Control (basal diet); SC (added 3 g/kg diet), SP (added 5% of the diet); SC and SP (added 3 g/kg SC and 5% SP of the diet). The entire experiment lasted 90 days. Blood samples were obtained by ear venipuncture on the 90th day. The CD4+ and CD8+ T lymphocyte values were determined by flow cytometry and cytokines (IFN-gamma and IL-4) were determined by ELISA. According to the results, there were no significant differences in the expression of cytokines, but serum CD4+/CD8+ increased in the animals fed SP and SC+SP supplemented diets (3 g/kg and 5% of the diet, respectively). It was concluded that S. platensis (A. platensis) may be used as an immune enhancer, although further studies are needed to clarify the effects of spirulina supplement on immunity.
dc.description.sponsorshipResearch Foundations of Uludag UniversityUludag University [2011/19]
dc.description.sponsorshipThis study was supported by a grant from the Research Foundations of Uludag University (Project number: 2011/19). Also, this manuscript was originated from the PhD thesis of Nilay Seyidoglu.
dc.identifier.doi10.4067/S0719-81322017000300185
dc.identifier.endpage190
dc.identifier.issn0719-8000
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85063431453
dc.identifier.scopusqualityQ2
dc.identifier.startpage185
dc.identifier.urihttps://doi.org/10.4067/S0719-81322017000300185
dc.identifier.urihttps://hdl.handle.net/20.500.11776/9375
dc.identifier.volume49
dc.identifier.wosWOS:000411173900007
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorSeyidoğlu, Nilay
dc.language.isoen
dc.publisherUniv Austral Chile, Fac Ciencias Veterinarias
dc.relation.ispartofAustral Journal of Veterinary Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectrabbits
dc.subjectSaccharomyces cerevisiae
dc.subjectSpirulina platensis
dc.subjectArthrospira platensis
dc.subjectimmunity
dc.subjectImmune-Response
dc.subjectEnhancement
dc.subjectExtract
dc.subjectHealth
dc.subjectGlucan
dc.subjectYeast
dc.titleThe effects of Spirulina platensis (Arthrospira platensis) and Saccharomyces cerevisiae on the distribution and cytokine production of CD4+and CD8+T-lymphocytes in rabbits
dc.typeArticle

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