The Effects of Fentanyl on Testicular Ischemia-Reperfusion Injury

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dc.contributor.authorMordeniz, Cengiz
dc.contributor.authorDemirkapu, Mahluga Jafarova
dc.contributor.authorAkgül, Murat
dc.contributor.authorKarabağ, Sevil
dc.contributor.authorÇelikkol, Aliye
dc.contributor.authorYananlı, Hasan Raci
dc.date.accessioned2022-05-11T13:01:14Z
dc.date.available2022-05-11T13:01:14Z
dc.date.issued2021
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Anesteziyoloji ve Reanimasyon Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Tıbbi Farmakoloji Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Üroloji Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Tıbbi Patoloji Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.description.abstractObjective: Testicular torsion is a condition that often occurs as a result of the rotation of the spermatic cord in childhood and adolescence in men, manifests with acute pain and causes infertility in the future even if emergency intervention is performed. The aim of this study is to investigate the protective and preventive effects of fentanyl, a potent analgesic agent frequently used in anaesthesia practice, on testicular ischemia–- reperfusion injury, which manifests through acute pain. Methods: A total of 16 adult male Wistar rats, weighing 200-250 g, were used in this study. They were divided into two groups, consisting of eight animals in each group. Torsion was created in all rats by rotating left testicles 720 clockwise on the day of the experiment. 3 mM of fentanyl was applied intraperitoneally 30 minutes before detorsion to the fentanyl group. Following an hour of ischemia, the left testicle was reinstated, and tissues were repaired according to their physiology. Following 24 hours of reperfusion, the animals were euthanised after taking left testes and blood samples. Results: Fentanyl, administered prior to testicular detorsion, significantly suppressed germ cell damage in torsioned tissue, catalase activity and malondialdehyde levels in blood samples taken from the heart. No significant differences were observed in plasma total thiol concentration, histological score, Leydig cell counts, percentage of necrosis and tubule rupture. Conclusion: These findings show that fentanyl administered before detortion creates a protective effect by preventing testicular ischemia–- reperfusion injury leading to infertility in the future.
dc.identifier.doi10.5152/TJAR.2021.1392
dc.identifier.endpage378
dc.identifier.issn2667-677X
dc.identifier.issn2667-6370
dc.identifier.issue5en_US
dc.identifier.scopus2-s2.0-85127108072
dc.identifier.scopusqualityQ3
dc.identifier.startpage373
dc.identifier.trdizinidTkRjM09UWXlNZz09
dc.identifier.urihttps://doi.org/10.5152/TJAR.2021.1392
dc.identifier.urihttps://app.trdizin.gov.tr/makale/TkRjM09UWXlNZz09
dc.identifier.urihttps://hdl.handle.net/20.500.11776/4432
dc.identifier.volume49
dc.identifier.wosWOS:000714664100005
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.institutionauthorMordeniz, Cengiz
dc.institutionauthorDemirkapu, Mahluga Jafarova
dc.institutionauthorAkgül, Murat
dc.institutionauthorKarabağ, Sevil
dc.institutionauthorÇelikkol, Aliye
dc.language.isoen
dc.relation.ispartofTurkish Journal of Anaesthesiology and Reanimation
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleThe Effects of Fentanyl on Testicular Ischemia-Reperfusion Injury
dc.typeArticle

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