Study on single crystal structure of the antimony(III) bromide complex with 3-methyl-2-mercaptobenzothiazole and biological activity of some antimony(III) bromide complexes with thioamides

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dc.authorscopusid36785856200
dc.authorscopusid12759726000
dc.authorscopusid54400030200
dc.authorscopusid6507202525
dc.authorscopusid6602925165
dc.authorscopusid56884173600
dc.authorscopusid6602706096
dc.contributor.authorÖztürk, İbrahim İsmet
dc.contributor.authorMetsios, A.K.
dc.contributor.authorFilimonova Orlova, Sofiye
dc.contributor.authorKourkoumelis, Nikolaos
dc.contributor.authorHadjikakou, Sotiris K.
dc.contributor.authorManos, Manolis
dc.contributor.authorHadjiliadis, Nick
dc.date.accessioned2022-05-11T14:29:48Z
dc.date.available2022-05-11T14:29:48Z
dc.date.issued2012
dc.departmentFakülteler, Fen Edebiyat Fakültesi, Kimya Bölümü
dc.description.abstractCrystals of the [SbBr3(MMBZT)2] (1) complex (MMBZT = N-methyl-2- mercaptobenzothiazole) were grown from acetonitrile/methanol of the filtrate derived from the reaction between 3-methyl-2-mercaptobenzo thiazole (MMBZT) in methanol, with antimony(III) bromide in acetonitrile. The crystal structure of 1 (C16H14 Br3N2S4Sb) was determined by X-ray diffraction at 100 (2) K, in space group P-1, with a = 10.738(2) A ? , b = 11.387(3) A ? , c = 11.439(3) A ? , a = 62.764°, b = 63.36 (2), c = 85.074(2), and Z = 2. The geometry around the metal center of complex 1 is square pyramidal, with two sulfur atoms from thione ligands and three bromide anions around Sb(III). Complex is monomer. The equatorial plane is formed by two sulfur and two bromide atoms in complex, in a cis-S, cis-Br arrangement. The in vitro cytotoxicity against leiomyosarcoma cells (LMS) of antimony(III) bromide complexes with thioamide ligands with formulae: [SbBr3(MMBZT)2] (1), [SbBr3(TU)2] (2), [SbBr3(MMI)2] (3), {[SbBr2(MBZIM)4][Br]-H2O} (4), {[SbBr2(l2-Br) (MMBZIM)2]2} (5), {[SbBr2(l2-Br)(EtMBZIM)2]2°MeOH} (6), {[SbBr3(l2-S-tHPMT)(tHPMT)]n} (7), {[SbBr2(l2-Br) (PYT)2)n} (8), {[SbBr2(l2-Br)(MTZD)2]n} (9), and {[SbBr5]2-[(PMTH2)2]} (10) (where TU = thiourea, MMI = methylimidazole, MBZIM = 2-mercaptobenzimidazole, MMBZIM = 2-mercapto-5-methyl-?enzimidazole, EtMBZIM = 5-ethoxy-2-mercaptobenzimidazole, tHPMT = 2-mercapto-3,4,5,6- tetrahydro-pyrimidine, PYT = 2-mercaptopyridine, MTZD = 2-mercapto-thiazolidine, and PMTH = 2-mercaptopyrimidine) were evaluated. Complex 8 shows the strongest activity against LMS cells with IC50 value 1.7 ± 0.1 ?L. The results are compared with their activity against human cervix carcinoma cell lines. Complexes 1, 6-9 were also tested for their inhibitory activity upon the catalytic peroxidation of linoleic acid to hydroperoxylinoleic acid by the enzyme lipoxygenase. Computational studies using multivariate linear regression and considering biological results (50% inhibitory concentration, IC 50) as dependent variables derived a theoretical equation for IC50 values of the complexes studied. The calculated IC50 values are compared adequately with the experimental inhibitory activity of the complexes measured. © Springer Science+Business Media, LLC 2011.
dc.description.sponsorshipAcknowledgments This research was carried out in partial fulfillment of the requirements for the Ph.D. thesis of I.I.O., under the supervision of S.K.H., at the University of Ioannina. S.K.H., N.H. and E.R.M would like to acknowledge a NATO grant for the exchange of scientists (PDD(CP)-(CBP.NR.NRCLG 983167). I.I.O. would like to thank the Hellenic Ministry of Education for a scholarship for postgraduate studies.
dc.identifier.doi10.1007/s00044-011-9905-9
dc.identifier.endpage3531
dc.identifier.issn1054-2523
dc.identifier.issue11en_US
dc.identifier.scopus2-s2.0-84871408032
dc.identifier.scopusqualityQ2
dc.identifier.startpage3523
dc.identifier.urihttps://doi.org/10.1007/s00044-011-9905-9
dc.identifier.urihttps://hdl.handle.net/20.500.11776/7137
dc.identifier.volume21
dc.indekslendigikaynakScopus
dc.institutionauthorÖztürk, İbrahim İsmet
dc.language.isoen
dc.relation.ispartofMedicinal Chemistry Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subject3-Methyl-2-mercaptobenzothiazole
dc.subjectAntimony(III) bromide complexes
dc.subjectAntitumor activity
dc.subjectBioinorganic medicinal chemistry
dc.subjectLipoxygenase
dc.subjectanion
dc.subjectantimony derivative
dc.subjectbenzothiazole derivative
dc.subjectbromine derivative
dc.subjectlinoleic acid
dc.subjectlipoxygenase
dc.subjectantineoplastic activity
dc.subjectarticle
dc.subjectatom
dc.subjectbiological activity
dc.subjectcancer cell
dc.subjectconcentration response
dc.subjectcrystal structure
dc.subjectcrystallization
dc.subjectcytotoxicity
dc.subjecthuman
dc.subjecthuman cell
dc.subjectIC 50
dc.subjectin vitro study
dc.subjectleiomyosarcoma
dc.subjectlipid peroxidation
dc.subjectstructure activity relation
dc.subjectuterine cervix carcinoma
dc.subjectX ray diffraction
dc.titleStudy on single crystal structure of the antimony(III) bromide complex with 3-methyl-2-mercaptobenzothiazole and biological activity of some antimony(III) bromide complexes with thioamides
dc.typeArticle

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