Angiotensin Converting Enzyme Gene Polymorphism in Turkish Asthmatic Patients

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dc.authorid0000-0001-5291-8620
dc.authorscopusid6507274799
dc.authorscopusid7004013184
dc.authorscopusid8416126500
dc.authorscopusid9247622400
dc.authorscopusid6701839731
dc.authorwosidBircan, Rıfat/A-7344-2018
dc.contributor.authorEryuksel, Emel
dc.contributor.authorCeyhan, Berrin Bagci
dc.contributor.authorBircan, Rifat
dc.contributor.authorAvşar, Melike
dc.contributor.authorÇirakoğlu, Beyazıt
dc.date.accessioned2022-05-11T14:28:23Z
dc.date.available2022-05-11T14:28:23Z
dc.date.issued2009
dc.departmentFakülteler, Fen Edebiyat Fakültesi, Biyoloji Bölümü
dc.description.abstractAsthma is a chronic inflammatory disease of the airways. Several candidate genes have been identified with a potential role in the pathogenesis of asthma, including the angiotensin converting enzyme (ACE) gene. We aimed to investigate the frequency of an ACE gene polymorphism in Turkish asthmatic patients and to determine its impact on clinical parameters and disease severity. Ninety-seven asthmatic patients (M/F 25/72, mean age 39 13 years) and 96 healthy subjects (M/F 26/70, mean age 38 12 years) were included. At baseline, all participants completed a questionnaire on demographics, symptoms, triggering factors, severity of asthma, and the presence of atopism. Blood samples were obtained from all patients and genomic DNA was isolated. The frequency of the ACE genotypes (I = insertion and D = deletion) among asthmatics and controls were compared: asthmatics showed a 40.2% prevalence of the DD genotype (n = 39), ID was 45.4% (n = 44), and II was 14.4% (n = 14.4). In the control subjects, the frequency of DD was18.8% (n = 18), ID was 50% (n = 48) and II was 31.3% (n = 30). The DD ACEgenotype was significantly more frequent in asthmatics compared with controls (p 0.001). Asthmatics with the ID ACE genotype showed a higher frequency of drug allergies, although this was not statistically significant (p = 0.08). Asthmatics with the DD genotype appeared to have a higher incidence of asthmatic episode exacerbations due to viral infections, but again this was not statistically significant (p = 0.08). Patients with mild or moderate-severe asthma had similar frequencies of these mutations. We found a higher frequency of the ACE DD gene mutation in Turkish asthmatic patients compared with non-asthmatics, suggesting that this ACE gene polymorphism may be a risk factor for asthma but does not increase the severity of the disease.
dc.identifier.doi10.1080/02770900802660972
dc.identifier.endpage338
dc.identifier.issn0277-0903
dc.identifier.issue4en_US
dc.identifier.pmid19484664
dc.identifier.scopus2-s2.0-67649767539
dc.identifier.scopusqualityQ2
dc.identifier.startpage335
dc.identifier.urihttps://doi.org/10.1080/02770900802660972
dc.identifier.urihttps://hdl.handle.net/20.500.11776/6809
dc.identifier.volume46
dc.identifier.wosWOS:000266489100003
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorBircan, Rifat
dc.language.isoen
dc.publisherTaylor & Francis Inc
dc.relation.ispartofJournal of Asthma
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectangiotensin converting enzyme gene polymorphism
dc.subjectasthma
dc.subjectdisease severity
dc.subjectDeletion Polymorphism
dc.subjectHigh-Frequency
dc.subjectAce
dc.subjectAssociation
dc.subjectAtopy
dc.subjectPrevalence
dc.subjectChildren
dc.subjectSystem
dc.subjectTissue
dc.subjectCough
dc.titleAngiotensin Converting Enzyme Gene Polymorphism in Turkish Asthmatic Patients
dc.typeArticle

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