Electrochemical Characteristics of a Novel Pyridinium Salt as a Candidate Drug Molecule and Its Interaction with DNA

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dc.authorid0000-0002-7816-3155
dc.authorid0000-0003-2759-4411
dc.authorid0000-0002-0788-8108
dc.authorscopusid36612616900
dc.authorscopusid55235059200
dc.authorscopusid35291427500
dc.authorscopusid35293209900
dc.authorscopusid6507417782
dc.authorwosidTOPKAYA, SEDA NUR/AAN-3669-2021
dc.authorwosidCetin, Arif/ABI-4321-2020
dc.authorwosidkarasakal, ayca/ABA-4762-2020
dc.contributor.authorTopkaya, Seda Nur
dc.contributor.authorKarasakal, Ayça
dc.contributor.authorÇetin, Arif E.
dc.contributor.authorParlar, Sülünay
dc.contributor.authorAlptüzün, Vildan
dc.date.accessioned2022-05-11T14:31:03Z
dc.date.available2022-05-11T14:31:03Z
dc.date.issued2020
dc.departmentFakülteler, Fen Edebiyat Fakültesi, Kimya Bölümü
dc.description.abstractIn this article, for the first time, the electrochemical properties of a novel pyridine derivative, 4-(2-(2-hydroxybenzylidene) hydrazinyl)-1-(3-phenylpropyl) pyridinium bromide (abbreviated as 4-Pyri), and its interaction with double stranded DNA (dsDNA) was investigated. The interaction between candidate drug molecule (4-Pyri) and dsDNA was analyzed by examining 4-Pyri (+0.6 V and +0.8 V) and guanine (+1.0 V) oxidation signal changes with Differential Pulse Voltammetry (DPV) and Cyclic Voltammetry (CV). Electrochemical Impedance Spectroscopy (EIS) was used to show the resistance changes before and after the interaction between 4-Pyri and dsDNA. We showed that after the interaction with 4-Pyri, the oxidation currents of guanine decreased dramatically, whereas the intrinsic oxidation currents of 4-Pyri dramatically increased. 4-Pyri oxidation current differences before and after the interaction with dsDNA enabled us to determine such interaction separately from guanine oxidation signals. In addition, resistance differences were observed at before and after the interaction with each other that confirmed the possible interaction. In addition, toxicity effect (S%) value, which is an important parameter for electrochemical studies indicated 4-Pyri's toxicity to dsDNA. Our results demonstrated that 4-Pyri interacts with dsDNA, and could be used as a potential candidate drug molecule due to its remarkable impact on dsDNA.
dc.description.sponsorshipTUBITAK BIDEB Program 2218Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [1929B011800172]
dc.description.sponsorshipAyca Karasakal kindly acknowledges TUBITAK BIDEB Program 2218 for the bursary during her research at Izmir Katip Celebi University (1929B011800172).
dc.identifier.doi10.1002/elan.202000012
dc.identifier.endpage1787
dc.identifier.issn1040-0397
dc.identifier.issn1521-4109
dc.identifier.issue8en_US
dc.identifier.scopus2-s2.0-85083993552
dc.identifier.scopusqualityQ2
dc.identifier.startpage1780
dc.identifier.urihttps://doi.org/10.1002/elan.202000012
dc.identifier.urihttps://hdl.handle.net/20.500.11776/7300
dc.identifier.volume32
dc.identifier.wosWOS:000529171100001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorKarasakal, Ayça
dc.language.isoen
dc.publisherWiley-V C H Verlag Gmbh
dc.relation.ispartofElectroanalysis
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCandidate Drug
dc.subjectdsDNA
dc.subjectDNA-Drug Interaction
dc.subjectVoltammetry
dc.subjectElectrochemical Impedance Spectroscopy
dc.subjectCyclic Voltammetry
dc.subjectBiological Evaluation
dc.subjectBinding
dc.subjectDsdna
dc.subjectElectrode
dc.subjectDerivatives
dc.subjectInhibitors
dc.subjectBiosensor
dc.subjectOxidation
dc.subjectDocking
dc.titleElectrochemical Characteristics of a Novel Pyridinium Salt as a Candidate Drug Molecule and Its Interaction with DNA
dc.typeArticle

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