The protective effects of endothelin-A receptor antagonist BQ-123 in pentylenetetrazole-induced seizure in rats

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dc.authorid0000-0001-8013-3302
dc.authorscopusid7006831777
dc.authorscopusid23988674500
dc.authorscopusid54387060700
dc.authorscopusid49461500100
dc.authorscopusid8502405200
dc.contributor.authorErdoğan, Hasan
dc.contributor.authorEkici, F.
dc.contributor.authorKatar, M.
dc.contributor.authorKesici, H.
dc.contributor.authorAslan, H.
dc.date.accessioned2022-05-11T14:41:23Z
dc.date.available2022-05-11T14:41:23Z
dc.date.issued2014
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Ana Bilim Dalı
dc.description.abstractEndothelin-1 has been shown to increase neuronal activity and glutaminergic synaptic transmission by endothelin-A receptors (ETAR) in the nucleus tractus solitarius neurons that play an important role in epileptic seizures. Therefore, BQ-I23 as an ETAR antagonist might attenuate neuronal excitability and glutaminergic synaptic transmission. The main purpose of the present study is to investigate the protective effect of acute BQ-123 treatment against pentylenetetrazole (PTZ)-induced tonic-clonic seizures. Wistar albino rats were divided into three groups: control, PTZ, and PTZ + BQ-123 groups. BQ-123 (3 mg/kg, intravenously) was administered for 15 min before injecting with PTZ (50 mg/kg, intraperitoneally). We determined a delay resulting from BQ-123 in duration of the seizure onset. Number of rats with major seizure also decreased according to scoring with video camera in PTZ + BQ-123 group. In BQ-123-treated group, there were eight rats without a major seizure, but only one rat had a delayed major seizure. The brain tissue glutathione peroxidase activity was significantly decreased in the PTZ and PTZ BQ-123 groups. According to the results of the control group, there was a significant increase in the protein carbonyl levels of the PTZ group and a significant increase in the nitric oxide levels of the PTZ + BQ-123 group. Histological examination showed an increase in the number of neuronal hyperchromatic nucleus especially in hippocampal gyrus dentatus region of BQ-123-treated group. We concluded that BQ-123 impeded the formation and spread of seizure to a great degree. The beneficial effects of BQ-I23 were comparatively supported with biochemical parameters and histological examinations.
dc.description.sponsorshipScientific Research Fund of Gaziosmanpasa University, Tokat, TurkeyGaziosmanpasa University
dc.description.sponsorshipThis research was supported and approved by The Scientific Research Fund of Gaziosmanpasa University, Tokat, Turkey.
dc.identifier.doi10.1177/0960327113520017
dc.identifier.endpage1016
dc.identifier.issn0960-3271
dc.identifier.issn1477-0903
dc.identifier.issue10en_US
dc.identifier.pmid24449761
dc.identifier.scopus2-s2.0-84921019847
dc.identifier.scopusqualityQ2
dc.identifier.startpage1008
dc.identifier.urihttps://doi.org/10.1177/0960327113520017
dc.identifier.urihttps://hdl.handle.net/20.500.11776/9163
dc.identifier.volume33
dc.identifier.wosWOS:000343382400003
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorErdoğan, Hasan
dc.language.isoen
dc.publisherSage Publications Ltd
dc.relation.ispartofHuman & Experimental Toxicology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectPentylenetetrazole
dc.subjectseizure
dc.subjectBQ-123
dc.subjectendothelin receptor antagonist
dc.subjectInduced Epileptiform Activity
dc.subjectIschemia-Reperfusion Injury
dc.subjectAcid Phenethyl Ester
dc.subjectAlpha-Tocopherol
dc.subjectNitric-Oxide
dc.subjectSuperoxide-Dismutase
dc.subjectCell-Proliferation
dc.subjectOxidative Stress
dc.subjectDentate Gyrus
dc.subjectBrain
dc.titleThe protective effects of endothelin-A receptor antagonist BQ-123 in pentylenetetrazole-induced seizure in rats
dc.typeArticle

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