Synthesis, Characterization, Anti-bacterial and Antiinflammatory Activities of Bismuth(III) Complexes Based on 5-chloro-2-mercaptobenzothiazole

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dc.contributor.authorÖztürk, İbrahim İsmet
dc.contributor.authorGürgan, Muazzez
dc.date.accessioned2023-05-06T17:19:31Z
dc.date.available2023-05-06T17:19:31Z
dc.date.issued2022
dc.departmentFakülteler, Fen Edebiyat Fakültesi, Kimya Bölümü
dc.departmentFakülteler, Fen Edebiyat Fakültesi, Biyoloji Bölümü
dc.description.abstractBismuth, known as a heavy metal, is excluded from this class due to its low toxicity. Due to this feature, bismuth containing compounds have always been interesting compounds in the field of medicinal chemistry. For this reason, the discovery of new bismuth compounds and the investigation of their biological properties are very important for this field. In this study, three new bismuth(III) compounds formulated as [Bi(L)2X3] (L: 5-chloro-2-mercaptobenzothiazole (ClMBZT); X: Cl, Br, and I) were synthesized for the first time and, the molecular structure of them were elucidated by a series of spectroscopic techniques. Thermal stability and degradation steps of the title compounds were analyzed by Thermogravimetric-Differential Thermal Analysis (TG-DTA). The antibacterial study has been conducted against six strains bacteria, and the results indicated that bismuth(III) compounds generally showed more effective antibacterial activity than free ligand. The anti-inflammatory potential of bismuth(III) compounds was investigated through in vitro lipoxygenase enzyme inhibition studies. The results show that bismuth(III) compounds have higher anti-inflammatory potential than free ligand.
dc.identifier.doi10.17350/HJSE19030000275
dc.identifier.endpage233
dc.identifier.issn2149-2123
dc.identifier.issn2148-4171
dc.identifier.issue3en_US
dc.identifier.startpage225
dc.identifier.trdizinid1137859
dc.identifier.urihttps://doi.org/10.17350/HJSE19030000275
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1137859
dc.identifier.urihttps://hdl.handle.net/20.500.11776/11826
dc.identifier.volume9
dc.indekslendigikaynakTR-Dizin
dc.institutionauthorÖztürk, İbrahim İsmet
dc.institutionauthorGürgan, Muazzez
dc.language.isoen
dc.relation.ispartofHittite Journal of Science and Engineering
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleSynthesis, Characterization, Anti-bacterial and Antiinflammatory Activities of Bismuth(III) Complexes Based on 5-chloro-2-mercaptobenzothiazole
dc.typeArticle

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