Vasodilation Responses to Non-Selective alpha-Adrenergic Blockage of Coronary Bypass Grafts in Diabetic and Non-Diabetic Patients: in Vitro Study

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dc.authorid0000-0001-7341-4907
dc.authorscopusid14008084500
dc.authorscopusid10139012600
dc.authorscopusid55317577700
dc.authorscopusid11440747800
dc.authorscopusid7004591561
dc.authorwosidGurkan, Selami/AAA-9006-2022
dc.authorwosidgocmez, semil selcen/G-2401-2018
dc.authorwosidgur, ozcan/AAA-8847-2022
dc.contributor.authorGürkan, Selami
dc.contributor.authorGür, Özcan
dc.contributor.authorÖzkaramanlı Gür, Demet
dc.contributor.authorGöçmez, Semil Selcen
dc.contributor.authorEge, Turan
dc.date.accessioned2022-05-11T14:13:57Z
dc.date.available2022-05-11T14:13:57Z
dc.date.issued2015
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kalp ve Damar Cerrahisi Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Tıbbi Farmakoloji Ana Bilim Dalı
dc.description.abstractBackground: Adrenergic tonus is increased in atherosclerotic coronary arteries. In this study, we aimed to demonstrate in vitro effects of phentolamine, a reversible nonselective alpha (a) adrenergic blocker, on coronary artery bypass grafts (CABG) and compare its effects in diabetic and nondiabetic patients. Methods: A total number of 30 patients (15 diabetic and 15 nondiabetic) who were assigned to elective CABG surgery were enrolled into the study. For both groups of patients, 16 internal mammarian artery (IMA) samples, 16 saphenous vein (SV) samples and 16 radial artery (RA) samples were collected and studied in the tissue bath system. The vasodilatation responses to increasing doses of phentolamine were recorded. Results: When grafts were compared in terms of amount of vasodilatation to phentolamine, IMA had the most prominent vasodilatation followed by RA and SV respectively. Although the vasodilatation responses in nondiabetic patients were numerically higher than diabetic patients, there was no statistically difference between the groups. Conclusion: Phentolamine, a nonselective a adrenergic blocker, is proven to have equal vasodilatory effects in diabetic and nondiabetic CABG grafts and can safely be used both intravenously and topically in the perioperative period.
dc.identifier.doi10.5761/atcs.oa.14-00176
dc.identifier.endpage150
dc.identifier.issn1341-1098
dc.identifier.issn2186-1005
dc.identifier.issue2en_US
dc.identifier.pmid25273273
dc.identifier.scopus2-s2.0-84928034096
dc.identifier.scopusqualityQ2
dc.identifier.startpage146
dc.identifier.urihttps://doi.org/10.5761/atcs.oa.14-00176
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5714
dc.identifier.volume21
dc.identifier.wosWOS:000353145700009
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorGürkan, Selami
dc.institutionauthorGür, Özcan
dc.institutionauthorGöçmez, Semil Selcen
dc.language.isoen
dc.publisherMedical Tribune Inc
dc.relation.ispartofAnnals of Thoracic and Cardiovascular Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectphentolamine
dc.subjectcoronary artery bypass graft
dc.subjectvasodilatation
dc.subjectVasoconstriction
dc.subjectArtery
dc.subjectPhentolamine
dc.subjectConstriction
dc.titleVasodilation Responses to Non-Selective alpha-Adrenergic Blockage of Coronary Bypass Grafts in Diabetic and Non-Diabetic Patients: in Vitro Study
dc.typeArticle

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