Vasodilation Responses to Non-Selective alpha-Adrenergic Blockage of Coronary Bypass Grafts in Diabetic and Non-Diabetic Patients: in Vitro Study
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Date
2015
Journal Title
Journal ISSN
Volume Title
Publisher
Medical Tribune Inc
Access Rights
info:eu-repo/semantics/openAccess
Abstract
Background: Adrenergic tonus is increased in atherosclerotic coronary arteries. In this study, we aimed to demonstrate in vitro effects of phentolamine, a reversible nonselective alpha (a) adrenergic blocker, on coronary artery bypass grafts (CABG) and compare its effects in diabetic and nondiabetic patients. Methods: A total number of 30 patients (15 diabetic and 15 nondiabetic) who were assigned to elective CABG surgery were enrolled into the study. For both groups of patients, 16 internal mammarian artery (IMA) samples, 16 saphenous vein (SV) samples and 16 radial artery (RA) samples were collected and studied in the tissue bath system. The vasodilatation responses to increasing doses of phentolamine were recorded. Results: When grafts were compared in terms of amount of vasodilatation to phentolamine, IMA had the most prominent vasodilatation followed by RA and SV respectively. Although the vasodilatation responses in nondiabetic patients were numerically higher than diabetic patients, there was no statistically difference between the groups. Conclusion: Phentolamine, a nonselective a adrenergic blocker, is proven to have equal vasodilatory effects in diabetic and nondiabetic CABG grafts and can safely be used both intravenously and topically in the perioperative period.
Description
Keywords
phentolamine, coronary artery bypass graft, vasodilatation, Vasoconstriction, Artery, Phentolamine, Constriction
Journal or Series
Annals of Thoracic and Cardiovascular Surgery
WoS Q Value
Q4
Scopus Q Value
Q2
Volume
21
Issue
2
