Bismuth(III) bromide-thioamide complexes: synthesis, characterization and cytotoxic properties

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dc.authorid0000-0003-3164-0038
dc.authorid0000-0002-4804-3822
dc.authorid0000-0001-6727-2711
dc.authorid0000-0001-7202-9169
dc.authorid0000-0003-0377-2260
dc.authorid0000-0001-9556-6266
dc.authorscopusid7102361709
dc.authorscopusid36785856200
dc.authorscopusid46860923200
dc.authorscopusid14525091600
dc.authorscopusid15127662100
dc.authorscopusid6602706096
dc.authorscopusid57209326301
dc.authorwosidOzturk, Ibrahim Ismet/K-1352-2013
dc.contributor.authorÇakmak, Mehmet
dc.contributor.authorÖztürk, İbrahim İsmet
dc.contributor.authorBanti, Christina N.
dc.contributor.authorManoli, Maria
dc.contributor.authorMoushi, E.
dc.contributor.authorTasiopoulos, Anastasios J.
dc.contributor.authorHadjikakou, Sotiris K.
dc.date.accessioned2022-05-11T14:30:58Z
dc.date.available2022-05-11T14:30:58Z
dc.date.issued2018
dc.departmentFakülteler, Fen Edebiyat Fakültesi, Kimya Bölümü
dc.description.abstractNew bismuth(III) bromine compounds of the heterocyclic thioamides were prepared and structurally characterized. The reaction of heterocyclic thioamides with bismuth(III) bromide resulted in the formation of the {[BiBr2(mu(2)-Br)(MMI)(2)](2)center dot CH3COCH3 center dot H2O} (1), {[BiBr2(MBZIM)(4)]center dot Br center dot 2H(2)O} (2), {[BiBr2(mu(2)-Br)(tHPMT)(2)](2)center dot CH3CN} (3), {[BiBr2(mu(2)-Br)(PYT)(2)](2)center dot CH3CN} (4) and {[BiBr2(mu(2)-Br)(MBZT)(2)](2) 2CH(3)OH} (5) complexes (MMI: 2-mercapto-1-methylimidazole, MBZIM: 2-mercaptobenzimidazole, tHPMT: 2-mercapto-3,4,5,6-tetrahydro-pyrimidine, PYT: 2-mercaptopyridine and MBZT: 2-mercaptobenzothiazole). The complexes 1-5 were characterized by melting point (m.p.), elemental analysis (c.a.), molar conductivity, Fourier-transform infrared (FT-IR), Fourier-transform Raman (FT-Raman), nuclear magnetic resonance (H-1 and (CNMR)-C-13) spectroscopy, UV-Vis spectroscopy and thermogravimetric-differential thermal analysis (TG-DTA). The molecular structures of 1-5 were determined by single-crystal X-ray diffraction. Complex 2 is a first ionic monomuclear octahedral bismuth(III) bromide, while the complexes 1,3-5 are the first examples of dinuclear bismuth(III) bromide derivatives. Complexes 1-5 were evaluated in terms of their in vitro cytotoxic activity against human adenocarcinoma breast (MCF-7) and cervix (HeLa) cells. The toxicity on normal human fetal lung fibroblast cells (MRC-5) was also evaluated. Moreover, the complexes 1-5 and free heterocyclic thioamide ligands were studied upon the catalytic peroxidation of the linoleic acid by the enzyme lipoxygenase (LOX).
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [114Z457]
dc.description.sponsorship(a) I.I.O. and M.C. acknowledge the financial support from The Scientific and Technological Research Council of Turkey (TUBITAK, Project No. 114Z457). (b) CNB and SKH would like to thank the Unit of Bioactivity Testing of Xenobiotics of the University of Ioannina for providing access to their facilities. (c) The International Graduate Program in 'Biological Inorganic Chemistry', which operates at the University of Ioannina within the collaboration of the Departments of Chemistry of the Universities of Ioannina, Athens, Thessaloniki, Patras, Crete and the Department of Chemistry of the University of Cyprus (http://bic.chem.uoi.gr/BIC-En/index-en.html), is acknowledged for the stimulating discussion forum.
dc.identifier.doi10.1515/mgmc-2018-0035
dc.identifier.endpage154
dc.identifier.issn0792-1241
dc.identifier.issn2191-0219
dc.identifier.issue45448en_US
dc.identifier.scopus2-s2.0-85054411302
dc.identifier.scopusqualityQ3
dc.identifier.startpage143
dc.identifier.urihttps://doi.org/10.1515/mgmc-2018-0035
dc.identifier.urihttps://hdl.handle.net/20.500.11776/7260
dc.identifier.volume41
dc.identifier.wosWOS:000451003600002
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorÇakmak, Mehmet
dc.institutionauthorÖztürk, İbrahim İsmet
dc.language.isoen
dc.publisherWalter De Gruyter Gmbh
dc.relation.ispartofMain Group Metal Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectbiological inorganic chemistry
dc.subjectbismuth(III) bromide
dc.subjectcytotoxicity
dc.subjectthioamides
dc.subjectAntimony(Iii) Halide-Complexes
dc.subjectHuman Breast-Cancer
dc.subjectStructural-Characterization
dc.subjectCrystal-Structure
dc.subjectIn-Vitro
dc.subjectBiological-Activity
dc.subjectChloride Complexes
dc.subjectX-Ray
dc.subjectThiourea
dc.subjectCatalysts
dc.titleBismuth(III) bromide-thioamide complexes: synthesis, characterization and cytotoxic properties
dc.typeArticle

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