Bismuth(III) bromide-thioamide complexes: synthesis, characterization and cytotoxic properties
dc.authorid | 0000-0003-3164-0038 | |
dc.authorid | 0000-0002-4804-3822 | |
dc.authorid | 0000-0001-6727-2711 | |
dc.authorid | 0000-0001-7202-9169 | |
dc.authorid | 0000-0003-0377-2260 | |
dc.authorid | 0000-0001-9556-6266 | |
dc.authorscopusid | 7102361709 | |
dc.authorscopusid | 36785856200 | |
dc.authorscopusid | 46860923200 | |
dc.authorscopusid | 14525091600 | |
dc.authorscopusid | 15127662100 | |
dc.authorscopusid | 6602706096 | |
dc.authorscopusid | 57209326301 | |
dc.authorwosid | Ozturk, Ibrahim Ismet/K-1352-2013 | |
dc.contributor.author | Çakmak, Mehmet | |
dc.contributor.author | Öztürk, İbrahim İsmet | |
dc.contributor.author | Banti, Christina N. | |
dc.contributor.author | Manoli, Maria | |
dc.contributor.author | Moushi, E. | |
dc.contributor.author | Tasiopoulos, Anastasios J. | |
dc.contributor.author | Hadjikakou, Sotiris K. | |
dc.date.accessioned | 2022-05-11T14:30:58Z | |
dc.date.available | 2022-05-11T14:30:58Z | |
dc.date.issued | 2018 | |
dc.department | Fakülteler, Fen Edebiyat Fakültesi, Kimya Bölümü | |
dc.description.abstract | New bismuth(III) bromine compounds of the heterocyclic thioamides were prepared and structurally characterized. The reaction of heterocyclic thioamides with bismuth(III) bromide resulted in the formation of the {[BiBr2(mu(2)-Br)(MMI)(2)](2)center dot CH3COCH3 center dot H2O} (1), {[BiBr2(MBZIM)(4)]center dot Br center dot 2H(2)O} (2), {[BiBr2(mu(2)-Br)(tHPMT)(2)](2)center dot CH3CN} (3), {[BiBr2(mu(2)-Br)(PYT)(2)](2)center dot CH3CN} (4) and {[BiBr2(mu(2)-Br)(MBZT)(2)](2) 2CH(3)OH} (5) complexes (MMI: 2-mercapto-1-methylimidazole, MBZIM: 2-mercaptobenzimidazole, tHPMT: 2-mercapto-3,4,5,6-tetrahydro-pyrimidine, PYT: 2-mercaptopyridine and MBZT: 2-mercaptobenzothiazole). The complexes 1-5 were characterized by melting point (m.p.), elemental analysis (c.a.), molar conductivity, Fourier-transform infrared (FT-IR), Fourier-transform Raman (FT-Raman), nuclear magnetic resonance (H-1 and (CNMR)-C-13) spectroscopy, UV-Vis spectroscopy and thermogravimetric-differential thermal analysis (TG-DTA). The molecular structures of 1-5 were determined by single-crystal X-ray diffraction. Complex 2 is a first ionic monomuclear octahedral bismuth(III) bromide, while the complexes 1,3-5 are the first examples of dinuclear bismuth(III) bromide derivatives. Complexes 1-5 were evaluated in terms of their in vitro cytotoxic activity against human adenocarcinoma breast (MCF-7) and cervix (HeLa) cells. The toxicity on normal human fetal lung fibroblast cells (MRC-5) was also evaluated. Moreover, the complexes 1-5 and free heterocyclic thioamide ligands were studied upon the catalytic peroxidation of the linoleic acid by the enzyme lipoxygenase (LOX). | |
dc.description.sponsorship | Scientific and Technological Research Council of Turkey (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [114Z457] | |
dc.description.sponsorship | (a) I.I.O. and M.C. acknowledge the financial support from The Scientific and Technological Research Council of Turkey (TUBITAK, Project No. 114Z457). (b) CNB and SKH would like to thank the Unit of Bioactivity Testing of Xenobiotics of the University of Ioannina for providing access to their facilities. (c) The International Graduate Program in 'Biological Inorganic Chemistry', which operates at the University of Ioannina within the collaboration of the Departments of Chemistry of the Universities of Ioannina, Athens, Thessaloniki, Patras, Crete and the Department of Chemistry of the University of Cyprus (http://bic.chem.uoi.gr/BIC-En/index-en.html), is acknowledged for the stimulating discussion forum. | |
dc.identifier.doi | 10.1515/mgmc-2018-0035 | |
dc.identifier.endpage | 154 | |
dc.identifier.issn | 0792-1241 | |
dc.identifier.issn | 2191-0219 | |
dc.identifier.issue | 45448 | en_US |
dc.identifier.scopus | 2-s2.0-85054411302 | |
dc.identifier.scopusquality | Q3 | |
dc.identifier.startpage | 143 | |
dc.identifier.uri | https://doi.org/10.1515/mgmc-2018-0035 | |
dc.identifier.uri | https://hdl.handle.net/20.500.11776/7260 | |
dc.identifier.volume | 41 | |
dc.identifier.wos | WOS:000451003600002 | |
dc.identifier.wosquality | Q4 | |
dc.indekslendigikaynak | Web of Science | |
dc.indekslendigikaynak | Scopus | |
dc.institutionauthor | Çakmak, Mehmet | |
dc.institutionauthor | Öztürk, İbrahim İsmet | |
dc.language.iso | en | |
dc.publisher | Walter De Gruyter Gmbh | |
dc.relation.ispartof | Main Group Metal Chemistry | |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.subject | biological inorganic chemistry | |
dc.subject | bismuth(III) bromide | |
dc.subject | cytotoxicity | |
dc.subject | thioamides | |
dc.subject | Antimony(Iii) Halide-Complexes | |
dc.subject | Human Breast-Cancer | |
dc.subject | Structural-Characterization | |
dc.subject | Crystal-Structure | |
dc.subject | In-Vitro | |
dc.subject | Biological-Activity | |
dc.subject | Chloride Complexes | |
dc.subject | X-Ray | |
dc.subject | Thiourea | |
dc.subject | Catalysts | |
dc.title | Bismuth(III) bromide-thioamide complexes: synthesis, characterization and cytotoxic properties | |
dc.type | Article |
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