Tumour necrosis factor like cytokine 1A levels and lesion complexity in non-smoking patients with coronary artery disease

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dc.authorid0000-0003-3720-0076
dc.authorid0000-0003-3304-4125
dc.authorscopusid16315021800
dc.authorscopusid55317577700
dc.authorscopusid6505680586
dc.authorscopusid23968920100
dc.contributor.authorAkyüz, Aydın
dc.contributor.authorÖzkaramanlı Gür, Demet
dc.contributor.authorAlpsoy, Şeref
dc.contributor.authorGüzel, Savaş
dc.date.accessioned2022-05-11T14:14:05Z
dc.date.available2022-05-11T14:14:05Z
dc.date.issued2019
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Kardiyoloji Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.description.abstractBackground: Tumour necrosis factor like cytokine 1A (TL1A), which is a member of tumour necrosis factor alpha superfamily (TNF-alpha), is a novel indicator of atherosclerosis. Objective: Smoking is an established stimulant of TNF-alpha. We aimed to investigate whether TLA1 plays a role in the presence and complexity of coronary artery atherosclerosis, exclusively in non-smoking patients with CAD. Methods: We enrolled 103 participants in the study, who underwent coronary angiography for stable angina pectoris. We divided the study population into 2 groups: The CAD group consisted of 62 patients with CAD and the control group consisted of 41 subjects with non-CAD. SYNTAX and Gensini scores, indicating CAD severity and complexity, were analysed as well as TLA1 levels. Results: TLA1 levels was higher in patients with CAD than those in controls (228[119-824] vs 178[15-418]pg/ml, p < 0.001). Presence of CAD (beta +/- SE = 106.29 +/- 33.11, p = 0.002), Syntax score (beta +/- SE= 6.57 +/- 1.75, p = 0.012), and Gensini score (beta +/- SE = 2.30 +/- 0.65, p = 0.001) were found to be predictors of TL1A levels. Gensini score and Syntax score were positively correlated with TL1A levels (r = 0.420, p < 0.001, and r = 0.402, p < 0.001, respectively). Conclusions: Non-smoker CAD patients have higher TLA1 levels that are promising biomarker for diagnosing CAD and indicating CAD lesion complexity.
dc.identifier.doi10.1080/1354750X.2019.1685004
dc.identifier.endpage770
dc.identifier.issn1354-750X
dc.identifier.issn1366-5804
dc.identifier.issue8en_US
dc.identifier.pmid31646918
dc.identifier.scopus2-s2.0-85074630877
dc.identifier.scopusqualityQ2
dc.identifier.startpage764
dc.identifier.urihttps://doi.org/10.1080/1354750X.2019.1685004
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5775
dc.identifier.volume24
dc.identifier.wosWOS:000494061100001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAkyüz, Aydın
dc.institutionauthorÖzkaramanlı Gür, Demet
dc.institutionauthorAlpsoy, Şeref
dc.institutionauthorGüzel, Savaş
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofBiomarkers
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectTumour necrosis factor ligand superfamily member 15
dc.subjectatherosclerosis
dc.subjectcoronary artery disease
dc.subjectgensini scoring
dc.subjectsyntax scoring
dc.subjectTnf-Like Ligand
dc.subjectCirculating Levels
dc.subjectDecoy Receptor-3
dc.subjectUp-Regulation
dc.subjectSmoking
dc.subjectTl1a
dc.subjectInflammation
dc.subjectCorrelate
dc.subjectImpact
dc.subjectAlpha
dc.titleTumour necrosis factor like cytokine 1A levels and lesion complexity in non-smoking patients with coronary artery disease
dc.typeArticle

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