Tumour necrosis factor like cytokine 1A levels and lesion complexity in non-smoking patients with coronary artery disease
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Dosyalar
Tarih
2019
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Taylor & Francis Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Background: Tumour necrosis factor like cytokine 1A (TL1A), which is a member of tumour necrosis factor alpha superfamily (TNF-alpha), is a novel indicator of atherosclerosis. Objective: Smoking is an established stimulant of TNF-alpha. We aimed to investigate whether TLA1 plays a role in the presence and complexity of coronary artery atherosclerosis, exclusively in non-smoking patients with CAD. Methods: We enrolled 103 participants in the study, who underwent coronary angiography for stable angina pectoris. We divided the study population into 2 groups: The CAD group consisted of 62 patients with CAD and the control group consisted of 41 subjects with non-CAD. SYNTAX and Gensini scores, indicating CAD severity and complexity, were analysed as well as TLA1 levels. Results: TLA1 levels was higher in patients with CAD than those in controls (228[119-824] vs 178[15-418]pg/ml, p < 0.001). Presence of CAD (beta +/- SE = 106.29 +/- 33.11, p = 0.002), Syntax score (beta +/- SE= 6.57 +/- 1.75, p = 0.012), and Gensini score (beta +/- SE = 2.30 +/- 0.65, p = 0.001) were found to be predictors of TL1A levels. Gensini score and Syntax score were positively correlated with TL1A levels (r = 0.420, p < 0.001, and r = 0.402, p < 0.001, respectively). Conclusions: Non-smoker CAD patients have higher TLA1 levels that are promising biomarker for diagnosing CAD and indicating CAD lesion complexity.
Açıklama
Anahtar Kelimeler
Tumour necrosis factor ligand superfamily member 15, atherosclerosis, coronary artery disease, gensini scoring, syntax scoring, Tnf-Like Ligand, Circulating Levels, Decoy Receptor-3, Up-Regulation, Smoking, Tl1a, Inflammation, Correlate, Impact, Alpha
Kaynak
Biomarkers
WoS Q Değeri
Q3
Scopus Q Değeri
Q2
Cilt
24
Sayı
8
