Methoxy-activated indole-7-carbohydrazides; synthesis, antioxidant, and anticancer properties

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dc.authorscopusid55326408200
dc.authorscopusid57240814700
dc.authorscopusid57880074500
dc.authorscopusid56572574200
dc.authorscopusid57542417200
dc.authorscopusid57201682024
dc.authorscopusid55308985300
dc.contributor.authorKandemir, Hakan
dc.contributor.authorIzgi, Samet
dc.contributor.authorÇınar, İrfan
dc.contributor.authorCebeci, Fatma
dc.contributor.authorDirican, Ebubekir
dc.contributor.authorSağlam, Mehmet F.
dc.contributor.authorŞengül, İbrahim F.
dc.date.accessioned2023-04-20T08:02:28Z
dc.date.available2023-04-20T08:02:28Z
dc.date.issued2022
dc.departmentFakülteler, Fen Edebiyat Fakültesi, Kimya Bölümü
dc.description.abstractIndole has been known as a key heterocyclic motif in the development of new structures for both chemical and biological properties. In this current study, a new range of indole-7-carbohydrazides has been successfully synthesized starting from the readily available 3-phenyl and 2,3-diphenyl 4,6-dimethoxyindoles. The structures of the novel compounds were confirmed by utilizing H-1 NMR, C-13 NMR, FT-IR, high-resolution mass spectrometry, and single crystal X- ray diffraction techniques. In addition, the indole-7-carbohydrazides showed promising antioxidant results in preliminary screens. Some of the new compounds generated from dimethoxy indoles were also screened for their anticancer activity against SH-SHY5Y (human neuroblastoma), AGS (human gastric adenocarcinoma), and MDA-MB-231 (human breast adenocarcinoma) cell lines. The results revealed that the compound 12 was the promising candidate, showing cytotoxic effects on both neuroblastoma, stomach, and breast cancer cells.
dc.description.sponsorshipTurkiye Bilimsel ve Teknolojik Arastirma Kurumu; Tekirdag Namik Kemal University [NKUBAP.01, 19.220]; Scientific and Technological Research Council of Turkey [120Z116]
dc.description.sponsorshipNAMIK KEMAL UNIVERSITESI; Turkiye Bilimsel ve Teknolojik Arastirma Kurumu; Tekirdag Namik Kemal University, Grant/Award Number: NKUBAP.01. GA.19.220; The Scientific and Technological Research Council of Turkey, Grant/Award Number: 120Z116
dc.identifier.doi10.1002/jhet.4562
dc.identifier.issn0022-152X
dc.identifier.issn1943-5193
dc.identifier.scopus2-s2.0-85137568357
dc.identifier.scopusqualityQ3
dc.identifier.urihttps://doi.org/10.1002/jhet.4562
dc.identifier.urihttps://hdl.handle.net/20.500.11776/10951
dc.identifier.wosWOS:000852569600001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorKandemir, Hakan
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofJournal of Heterocyclic Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAntiinflammatory Activity
dc.subjectIndole Alkaloids
dc.subjectInhibitors
dc.titleMethoxy-activated indole-7-carbohydrazides; synthesis, antioxidant, and anticancer properties
dc.typeArticle

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