Bismuth(III) halide complexes of aromatic thiosemicarbazones: Synthesis, structural characterization and biological evaluation

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dc.authorscopusid36785856200
dc.authorscopusid46860923200
dc.authorscopusid6602925165
dc.authorscopusid57196276440
dc.authorscopusid6602706096
dc.contributor.authorÖztürk, İbrahim İsmet
dc.contributor.authorBanti, Christina N.
dc.contributor.authorHadjikakou, Sotiris K.
dc.contributor.authorPanagiotou, Nikos
dc.contributor.authorTasiopoulos, Anastasios J.
dc.date.accessioned2022-05-11T14:04:39Z
dc.date.available2022-05-11T14:04:39Z
dc.date.issued2021
dc.departmentFakülteler, Fen Edebiyat Fakültesi, Kimya Bölümü
dc.description.abstractFour new bismuth(III) thiosemicarbazone complexes, {BiCl3(?1-S-Hacptsc)3} (1), {[BiBr3(?1-S-Hacptsc)3]·CH3OH} (2), {[BiI2(µ2-I](?1-S-Hacptsc)]2} (3) and {[BiCl2(µ2-Cl)(?1-S-Hbztsc)2]2} (4), were prepared with the ligands acetophenone thiosemicarbazone (Hacptsc) and benzaldehyde thiosemicarbazone (Hbztsc). The complexes were characterized by a series of spectroscopic techniques. The crystal structures of 1–4 were also determined by X-ray diffraction. To the best of our knowledge, complexes 1–4 are the first examples of bismuth(III) halide aromatic thiosemicarbazones. Hirshfeld surface analysis studies show that H…H and X…H/H…X interactions of complexes 1–4 play an important role in the formation of supramolecular aggregation. Complexes 1–4 have been tested for their in vitro cytotoxic activity against human breast adenocarcinoma (MCF-7) cells. The toxicity of 1–4 has been evaluated on normal human fetal lung fibroblast cells (MRC-5). Complexes 1–4 appeared to show low cytotoxic activity and low toxicity. The antibacterial activity of 1–4 and their ligands was evaluated against the Gram negative species Pseudomonas aeruginosa (P. aeruginosa) and Escherichia coli (E. coli) and Gram positive ones Staphylococcus epidermidis (S. epidermidis) and Staphylococcus aureus (S. aureus) by the Inhibition Zone (IZ) method. The influence of 1–4 on the catalytic peroxidation of linoleic acid by the enzyme lipoxygenase (LOX) has been determined experimentally. The IC50 values reveal that the synthesized bismuth(III) aromatic thiosemicarbazone complexes have good potential to inhibit lipoxygenase, with values better than the free aromatic thiosemicarbazone ligands and cisplatin. © 2021 Elsevier Ltd
dc.description.sponsorshipThis work was supported by the Tekirdag Namik Kemal University, Office of Scientific Research Projects (Project No. NKUBAP.01.GA.20.281).
dc.identifier.doi10.1016/j.poly.2021.115388
dc.identifier.issn0277-5387
dc.identifier.scopus2-s2.0-85111662852
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1016/j.poly.2021.115388
dc.identifier.urihttps://hdl.handle.net/20.500.11776/4694
dc.identifier.volume208
dc.identifier.wosWOS:000696897300003
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorÖztürk, İbrahim İsmet
dc.language.isoen
dc.publisherElsevier Ltd
dc.relation.ispartofPolyhedron
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAromatic thiosemicarbazone
dc.subjectBiological activity
dc.subjectBismuth(III) halide
dc.subjectCrystal structure
dc.subjectHirshfeld surface analysis
dc.titleBismuth(III) halide complexes of aromatic thiosemicarbazones: Synthesis, structural characterization and biological evaluation
dc.typeArticle

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