Piperlongumine increases the apoptotic effect of doxorubicin and paclitaxel in a cervical cancer cell line

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dc.authorscopusid6701472672
dc.authorscopusid56769801000
dc.authorscopusid8666331800
dc.authorscopusid9242258800
dc.contributor.authorŞeber, Erdoğan Selçuk
dc.contributor.authorŞirin, Duygu Yaşar
dc.contributor.authorYetişyiğit, Tarkan
dc.contributor.authorBilgen, Türker
dc.date.accessioned2022-05-11T14:02:59Z
dc.date.available2022-05-11T14:02:59Z
dc.date.issued2020
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Radyasyon Onkolojisi Ana Bilim Dalı
dc.departmentYüksekokullar, Sağlık Yüksekokulu, Beslenme ve Diyetetik Bölümü
dc.description.abstractObjective: Piperlongumine (PL) is an alkaloid derived from the edible pepper (Piper longum L) and it has been described to have various biologic activities including anticancer effects. Our aim in this study was to assess the cytotoxic role of PL on a cervical cancer cell line (HeLa) and to evaluate the effects of PL/doxorubicin and PL/paclitaxel combination therapies on apoptotic cancer cell death. Material and Methods: The cytotoxicity, IC50 doses by MTT assay confirmed by fluorescent imaging, and apoptotic cell rates by Annexin V staining using flow cytometry were determined for PL, doxorubicin, paclitaxel, and for their combinations. Results: It was shown that the PL by itself induced the apoptosis in HeLa cells. PL in combination with doxorubicin and paclitaxel increased apoptotic cell death compared to either chemotherapeutic agent alone. Conclusion: We conclude that the PL inhibits cancer cell growth by inducing apoptosis and has a potential anticancer activity in cervical cancer, especially when combined with doxorubicin and paclitaxel. © 2020 Wolters Kluwer Medknow Publications. All rights reserved.
dc.identifier.doi10.4103/njcp.njcp_80_19
dc.identifier.endpage391
dc.identifier.issn1119-3077
dc.identifier.issue3en_US
dc.identifier.pmid32134040
dc.identifier.scopus2-s2.0-85081041148
dc.identifier.scopusqualityQ3
dc.identifier.startpage386
dc.identifier.urihttps://doi.org/10.4103/njcp.njcp_80_19
dc.identifier.urihttps://hdl.handle.net/20.500.11776/4562
dc.identifier.volume23
dc.identifier.wosWOS:000519642600018
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorŞeber, Erdoğan Selçuk
dc.institutionauthorŞirin, Duygu Yaşar
dc.institutionauthorYetişyiğit, Tarkan
dc.institutionauthorBilgen, Türker
dc.language.isoen
dc.publisherWolters Kluwer Medknow Publications
dc.relation.ispartofNigerian Journal of Clinical Practice
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectApoptosis
dc.subjectdoxorubicin
dc.subjectHeLa
dc.subjectpaclitaxel
dc.subjectpiperlongumine
dc.subject1,3 dioxolane derivative
dc.subjectantineoplastic agent
dc.subjectdoxorubicin
dc.subjectpaclitaxel
dc.subjectpiperlonguminine
dc.subjectapoptosis
dc.subjectdrug effect
dc.subjectdrug potentiation
dc.subjectfemale
dc.subjectHeLa cell line
dc.subjecthuman
dc.subjectuterine cervix tumor
dc.subjectAntineoplastic Agents
dc.subjectApoptosis
dc.subjectDioxolanes
dc.subjectDoxorubicin
dc.subjectDrug Synergism
dc.subjectFemale
dc.subjectHeLa Cells
dc.subjectHumans
dc.subjectPaclitaxel
dc.subjectUterine Cervical Neoplasms
dc.titlePiperlongumine increases the apoptotic effect of doxorubicin and paclitaxel in a cervical cancer cell line
dc.typeArticle

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