Piperlongumine increases the apoptotic effect of doxorubicin and paclitaxel in a cervical cancer cell line
Yükleniyor...
Dosyalar
Tarih
2020
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Wolters Kluwer Medknow Publications
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objective: Piperlongumine (PL) is an alkaloid derived from the edible pepper (Piper longum L) and it has been described to have various biologic activities including anticancer effects. Our aim in this study was to assess the cytotoxic role of PL on a cervical cancer cell line (HeLa) and to evaluate the effects of PL/doxorubicin and PL/paclitaxel combination therapies on apoptotic cancer cell death. Material and Methods: The cytotoxicity, IC50 doses by MTT assay confirmed by fluorescent imaging, and apoptotic cell rates by Annexin V staining using flow cytometry were determined for PL, doxorubicin, paclitaxel, and for their combinations. Results: It was shown that the PL by itself induced the apoptosis in HeLa cells. PL in combination with doxorubicin and paclitaxel increased apoptotic cell death compared to either chemotherapeutic agent alone. Conclusion: We conclude that the PL inhibits cancer cell growth by inducing apoptosis and has a potential anticancer activity in cervical cancer, especially when combined with doxorubicin and paclitaxel. © 2020 Wolters Kluwer Medknow Publications. All rights reserved.
Açıklama
Anahtar Kelimeler
Apoptosis, doxorubicin, HeLa, paclitaxel, piperlongumine, 1,3 dioxolane derivative, antineoplastic agent, doxorubicin, paclitaxel, piperlonguminine, apoptosis, drug effect, drug potentiation, female, HeLa cell line, human, uterine cervix tumor, Antineoplastic Agents, Apoptosis, Dioxolanes, Doxorubicin, Drug Synergism, Female, HeLa Cells, Humans, Paclitaxel, Uterine Cervical Neoplasms
Kaynak
Nigerian Journal of Clinical Practice
WoS Q Değeri
Q4
Scopus Q Değeri
Q3
Cilt
23
Sayı
3
