Altered thiol/disulfide homeostasis and ischemia-modified albumin levels in children with irritable bowel syndrome

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dc.authorscopusid55315126400
dc.authorscopusid55175886400
dc.authorscopusid8240771400
dc.authorscopusid36523620300
dc.authorscopusid29067508300
dc.authorscopusid57195410600
dc.authorscopusid7003566828
dc.contributor.authorDurankuş, Ferit
dc.contributor.authorŞenkal, E.
dc.contributor.authorÇam, Sebahat
dc.contributor.authorPotas, Nihan
dc.contributor.authorAlbayrak, Yakup
dc.contributor.authorNural, C.
dc.contributor.authorErel, Özcan
dc.date.accessioned2022-05-11T14:05:08Z
dc.date.available2022-05-11T14:05:08Z
dc.date.issued2021
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Ruh Sağlığı ve Hastalıkları Ana Bilim Dalı
dc.description.abstractBackground: In this study, we assessed thiol/disulfide homeostasis (TDH) parameters and ischemia-modified albumin (IMA) levels in children with irritable bowel syndrome (IBS) compared with healthy children. Methods: Fifty-six children with IBS and 53 healthy children were included in the study after assessment of inclusion and exclusion criteria. Plasma thiol/disulfide and IMA levels were compared between children with and without IBS. Results: The mean values of native thiol, total thiol, and disulfide were 343.779 (Formula presented.) 138.654 ?mol/L, 365.398 ± 140.148 ?mol/L, and 23.190 ± 4.978 ?mol/L, respectively, in the IBS group and 409.908 ± 69.288 ?mol/L, 433.481 ± 76.891 ?mol/L, and 20.090 ± 4.252 ?mol/L, respectively, in the control group. Native thiol and total thiol values were significantly reduced in the IBS group compared with the control group. The mean IMA values were 0.835 ± 0.083 (g/L) and 0.778 ± 0.072 in the IBS and control groups, respectively. The IMA value was significantly increased in the IBS group. Conclusion: Impaired thiol/disulfide homeostasis and increased IMA levels can be considered etiological factors in children with IBS. © 2020 Japan Pediatric Society
dc.identifier.doi10.1111/ped.14406
dc.identifier.endpage305
dc.identifier.issn1328-8067
dc.identifier.issue3en_US
dc.identifier.pmid32713058
dc.identifier.scopus2-s2.0-85102500015
dc.identifier.scopusqualityQ3
dc.identifier.startpage300
dc.identifier.urihttps://doi.org/10.1111/ped.14406
dc.identifier.urihttps://hdl.handle.net/20.500.11776/4905
dc.identifier.volume63
dc.identifier.wosWOS:000629305300001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAlbayrak, Yakup
dc.language.isoen
dc.publisherJohn Wiley and Sons Inc
dc.relation.ispartofPediatrics International
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectirritable bowel syndrome
dc.subjectoxidative stress
dc.subjectthiol
dc.subjectdisulfide
dc.subjectischemia modified albumin
dc.subjectthiol
dc.subjectbiological marker
dc.subjectdisulfide
dc.subjecthuman serum albumin
dc.subjectischemia-modified albumin
dc.subjectserum albumin
dc.subjectthiol derivative
dc.subjectadolescent
dc.subjectalbumin blood level
dc.subjectArticle
dc.subjectblood level
dc.subjectconstipation
dc.subjectcontrolled study
dc.subjectdiarrhea
dc.subjectfemale
dc.subjecthomeostasis
dc.subjecthuman
dc.subjectirritable colon
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectoxidative stress
dc.subjectpathogenesis
dc.subjectchild
dc.subjecthomeostasis
dc.subjectirritable colon
dc.subjectmetabolism
dc.subjectBiomarkers
dc.subjectChild
dc.subjectDisulfides
dc.subjectHomeostasis
dc.subjectHumans
dc.subjectIrritable Bowel Syndrome
dc.subjectOxidative Stress
dc.subjectSerum Albumin
dc.subjectSerum Albumin, Human
dc.subjectSulfhydryl Compounds
dc.titleAltered thiol/disulfide homeostasis and ischemia-modified albumin levels in children with irritable bowel syndrome
dc.typeArticle

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