Altered thiol/disulfide homeostasis and ischemia-modified albumin levels in children with irritable bowel syndrome
Yükleniyor...
Dosyalar
Tarih
2021
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
John Wiley and Sons Inc
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Background: In this study, we assessed thiol/disulfide homeostasis (TDH) parameters and ischemia-modified albumin (IMA) levels in children with irritable bowel syndrome (IBS) compared with healthy children. Methods: Fifty-six children with IBS and 53 healthy children were included in the study after assessment of inclusion and exclusion criteria. Plasma thiol/disulfide and IMA levels were compared between children with and without IBS. Results: The mean values of native thiol, total thiol, and disulfide were 343.779 (Formula presented.) 138.654 ?mol/L, 365.398 ± 140.148 ?mol/L, and 23.190 ± 4.978 ?mol/L, respectively, in the IBS group and 409.908 ± 69.288 ?mol/L, 433.481 ± 76.891 ?mol/L, and 20.090 ± 4.252 ?mol/L, respectively, in the control group. Native thiol and total thiol values were significantly reduced in the IBS group compared with the control group. The mean IMA values were 0.835 ± 0.083 (g/L) and 0.778 ± 0.072 in the IBS and control groups, respectively. The IMA value was significantly increased in the IBS group. Conclusion: Impaired thiol/disulfide homeostasis and increased IMA levels can be considered etiological factors in children with IBS. © 2020 Japan Pediatric Society
Açıklama
Anahtar Kelimeler
irritable bowel syndrome, oxidative stress, thiol, disulfide, ischemia modified albumin, thiol, biological marker, disulfide, human serum albumin, ischemia-modified albumin, serum albumin, thiol derivative, adolescent, albumin blood level, Article, blood level, constipation, controlled study, diarrhea, female, homeostasis, human, irritable colon, major clinical study, male, oxidative stress, pathogenesis, child, homeostasis, irritable colon, metabolism, Biomarkers, Child, Disulfides, Homeostasis, Humans, Irritable Bowel Syndrome, Oxidative Stress, Serum Albumin, Serum Albumin, Human, Sulfhydryl Compounds
Kaynak
Pediatrics International
WoS Q Değeri
Q4
Scopus Q Değeri
Q3
Cilt
63
Sayı
3
