Anti-GAD Encephalitis Following COVID-19 Vaccination: A Case Report

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dc.authoridALTUNAN, BENGU/0000-0001-6034-8808
dc.contributor.authorDeniz, Cigdem
dc.contributor.authorAltunan, Bengu
dc.contributor.authorUnal, Aysun
dc.date.accessioned2024-10-29T17:59:07Z
dc.date.available2024-10-29T17:59:07Z
dc.date.issued2023
dc.departmentTekirdağ Namık Kemal Üniversitesi
dc.description.abstractSince December 2020, a significantly higher number of people worldwide have been vaccinated for coronavirus disease 2019 (COVID-19). Neurological complications have been reported after these vaccines, although a definitive causal relationship has not been proven in the available literature. We describe a 51-year-old man presenting with anti-glutamic acid decarboxylase (anti-GAD) antibody positive autoimmune encephalitis with progressive cognitive impairment and behavioral abnormalities, presenting shortly after the second dose of mRNA COVID-19 vaccine, possibly representing a serious vaccine related adverse event. Response to high-dose steroid and intravenous immunoglobulin treatment was positive. As many people around the world have been vaccinated against COVID-19, this case shows that autoimmune encephalitis and even anti-GAD antibody positive autoimmune encephalitis can develop as a side effect after this new vaccine, but with early diagnosis and appropriate treatment, the clinic can have a good prognosis. Observational studies with large numbers of patients are needed to explain causality.
dc.identifier.doi10.29399/npa.28251
dc.identifier.endpage287
dc.identifier.issn1300-0667
dc.identifier.issn1309-4866
dc.identifier.issue3en_US
dc.identifier.pmid37645084
dc.identifier.scopus2-s2.0-85168563981
dc.identifier.scopusqualityQ3
dc.identifier.startpage283
dc.identifier.trdizinid1228589
dc.identifier.urihttps://doi.org/10.29399/npa.28251
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1228589
dc.identifier.urihttps://hdl.handle.net/20.500.11776/14630
dc.identifier.volume60
dc.identifier.wosWOS:001055620100014
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTurkish Neuropsychiatry Assoc-Turk Noropsikiyatri Dernegi
dc.relation.ispartofNoropsikiyatri Arsivi-Archives of Neuropsychiatry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectanti-GAD encephalitis
dc.subjectautoimmune encephalitis
dc.subjectCOVID-19 vaccination
dc.titleAnti-GAD Encephalitis Following COVID-19 Vaccination: A Case Report
dc.title.alternativeCOVID-19 Aşısını Takiben Gelişen Anti-GAD Ensefalit: Olgu Sunumu
dc.typeArticle

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