Copeptin as a Novel Biomarker in Nocturnal Enuresis

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dc.authorid0000-0002-4060-0583
dc.authorid0000-0001-5992-9488
dc.authorid0000-0001-6140-5181
dc.authorid0000-0002-5630-3399
dc.authorscopusid36165893600
dc.authorscopusid8416588900
dc.authorscopusid54791156900
dc.authorscopusid23968920100
dc.authorscopusid37058172000
dc.authorscopusid42661653300
dc.authorscopusid6601976056
dc.authorwosidDonma, Mustafa Metin/ABF-2169-2021
dc.authorwosidDonma, Metin/AAB-6079-2020
dc.authorwosidYazici, Cenk Murat/AAA-4330-2020
dc.authorwosidDonma, Orkide/AAI-1853-2019
dc.authorwosidNALBANTOGLU, BURCIN/A-5386-2018
dc.contributor.authorNalbantoğlu, Burçin
dc.contributor.authorYazıcı, Cenk Murat
dc.contributor.authorNalbantoğlu, Ayşin
dc.contributor.authorGüzel, Savaş
dc.contributor.authorTopçu, Birol
dc.contributor.authorGüzel, Eda Çelik
dc.contributor.authorMintaş, Nuriye Ece
dc.date.accessioned2022-05-11T14:07:34Z
dc.date.available2022-05-11T14:07:34Z
dc.date.issued2013
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Üroloji Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Biyoistatistik Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Aile Hekimliği Ana Bilim Dalı
dc.description.abstractOBJECTIVE To investigate the relation between copeptin, arginine vasopressin (AVP), and nocturnal enuresis (NE). METHODS Forty-four patients with NE and 44 healthy children aged between 6 and 14 years were enrolled. Patients with nonmonosymptomatic and secondary NE were excluded from the study. A small questionnaire, filled by parents, collected information about sociodemographic characteristics. Blood was obtained for plasma AVP and copeptin concentrations. RESULTS Copeptin levels were significantly lower in patient group (3.74 +/- 1.44 pg/mL) than the control group (16.57 +/- 3.91 pg/mL), whereas AVP levels were not significantly different between groups. Copeptin levels were significantly lower in patients (3.17 +/- 1.15 pg/mL) who had bed-wetting 2 or more nights a week, which is considered as severe bed-wetting, than the patients (4.95 +/- 1.24 pg/mL) who had bed-wetting 1 night or less than 1 night a week. CONCLUSION This study demonstrates the presence of decreased levels of copeptin in patients with NE compared with healthy patients. AVP levels were not different between groups. To our knowledge, this is the first report assessing the relationship between copeptin and NE. (C) 2013 Elsevier Inc.
dc.identifier.doi10.1016/j.urology.2013.05.047
dc.identifier.endpage1123
dc.identifier.issn0090-4295
dc.identifier.issn1527-9995
dc.identifier.issue5en_US
dc.identifier.pmid23958506
dc.identifier.scopus2-s2.0-84886951119
dc.identifier.scopusqualityQ2
dc.identifier.startpage1120
dc.identifier.urihttps://doi.org/10.1016/j.urology.2013.05.047
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5145
dc.identifier.volume82
dc.identifier.wosWOS:000326153300040
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorNalbanto?lu, Burçin
dc.institutionauthorYazıcı, Cenk Murat
dc.institutionauthorNalbantoğlu, Ayşin
dc.institutionauthorGüzel, Savaş
dc.institutionauthorTopçu, Birol
dc.institutionauthorGüzel, Eda Çelik
dc.institutionauthorMintaş, Nuriye Ece
dc.language.isoen
dc.publisherElsevier Science Inc
dc.relation.ispartofUrology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectBrain-Stem
dc.subjectVasopressin
dc.subjectPlasma
dc.subjectMechanisms
dc.subjectMarker
dc.titleCopeptin as a Novel Biomarker in Nocturnal Enuresis
dc.typeArticle

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