Copeptin as a Novel Biomarker in Nocturnal Enuresis
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Dosyalar
Tarih
2013
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier Science Inc
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
OBJECTIVE To investigate the relation between copeptin, arginine vasopressin (AVP), and nocturnal enuresis (NE). METHODS Forty-four patients with NE and 44 healthy children aged between 6 and 14 years were enrolled. Patients with nonmonosymptomatic and secondary NE were excluded from the study. A small questionnaire, filled by parents, collected information about sociodemographic characteristics. Blood was obtained for plasma AVP and copeptin concentrations. RESULTS Copeptin levels were significantly lower in patient group (3.74 +/- 1.44 pg/mL) than the control group (16.57 +/- 3.91 pg/mL), whereas AVP levels were not significantly different between groups. Copeptin levels were significantly lower in patients (3.17 +/- 1.15 pg/mL) who had bed-wetting 2 or more nights a week, which is considered as severe bed-wetting, than the patients (4.95 +/- 1.24 pg/mL) who had bed-wetting 1 night or less than 1 night a week. CONCLUSION This study demonstrates the presence of decreased levels of copeptin in patients with NE compared with healthy patients. AVP levels were not different between groups. To our knowledge, this is the first report assessing the relationship between copeptin and NE. (C) 2013 Elsevier Inc.
Açıklama
Anahtar Kelimeler
Brain-Stem, Vasopressin, Plasma, Mechanisms, Marker
Kaynak
Urology
WoS Q Değeri
Q2
Scopus Q Değeri
Q2
Cilt
82
Sayı
5
